[Genetic aspects of the reaction of humoral immunity to collagen in humans and animals. Report I. Analysis of polymorphism of autoantibody levels to collagen type I in mice NZB X NZW (F1)]
- PMID: 4018585
[Genetic aspects of the reaction of humoral immunity to collagen in humans and animals. Report I. Analysis of polymorphism of autoantibody levels to collagen type I in mice NZB X NZW (F1)]
Abstract
The study of polymorphism of humoral immunoreactions to the type I (AC) collagen in CBA/Lac, C57B1/6-J inbred mice and NZB X NZW (F1) hybrids showed the presence of genetically determined variability of the above mentioned trait. The analysis of intralinear dispersions of AC levels in NZB X NZW (F1) mice revealed sex dimorphism and age variability of the trait. A suggestion was made that sex hormones are important factors in ontogenic formation and modulation of autoimmunity to the type I collagen in NZB X NZW (F1) mice.
Similar articles
-
[Genetic aspects of the reactions of humoral immunity to collagen in man and animals. II. Modifications of the autoimmune status to collagen type I in NZB x NZW (F1) mice by sex hormones during ontogeny].Genetika. 1985 Jul;21(7):1236-8. Genetika. 1985. PMID: 4043731 Russian.
-
Backcross analysis of genes linked to autoantibody production in New Zealand White mice.J Immunol. 1996 Sep 15;157(6):2719-27. J Immunol. 1996. PMID: 8805679
-
Sex differences in the regulation of experimentally induced autoantibodies in (NZB x NZW)F1 mice.Immunology. 1980 Dec;41(4):819-23. Immunology. 1980. PMID: 6450727 Free PMC article.
-
IL-4Ralpha polymorphism in regulation of IL-4 synthesis by T cells: implication in susceptibility to a subset of murine lupus.Int Immunol. 2007 Feb;19(2):175-83. doi: 10.1093/intimm/dxl134. Epub 2006 Dec 22. Int Immunol. 2007. PMID: 17189592
-
The genetic origin of human autoantibodies.J Immunol. 1988 May 15;140(10):3283-5. J Immunol. 1988. PMID: 3283230 Review. No abstract available.