Precision Omics Initiative Sweden (PROMISE) will integrate research with healthcare

Anders Kämpe^{1

2}, Sanna Gudmundsson^{3

4}, Colum P Walsh^{5

6}, Kerstin Lindblad-Toh^{7

8

9}, Åsa Johansson^{8

10}, Anna Clareborn¹⁰, Adam Ameur^{8

10}, Anders Edsjö^{11

12}, Thoas Fioretos^{11

13

14}, Hans Ehrencrona^{11

13}, Daniel Eriksson¹⁰, Tove Fall^{8

15}, Paul W Franks^{16

17}, Ulf Gyllensten¹⁰, Margareta Haag¹⁸, Anna Hagwall¹⁹, Maria Johansson Soller¹, Janne Lehtiö²⁰, Yi Lu²¹, Patrik K E Magnusson²¹, Erik Melén²², Beatrice Melin²³, Karl Michaëlsson²⁴, Ann Nordgren^{1

2

25

26}, Jessica Nordlund^{8

15}, Lao H Saal²⁷, Jochen M Schwenk²⁸, Per Sikora^{25

29}, Johan Sundström^{15

30}, Fulya Taylan^{1

2}, Bethany Van Guelpen^{23

31}, Mia Wadelius^{8

15}, Anna Wedell^{1

32}, Valtteri Wirta^{2

3

33}, Päivi Östling^{8

20}, Bo Jacobsson^{34

35

36}, Tobias Sjöblom^{8

10}, Bengt Persson¹⁹, Richard Rosenquist^{37

38}, Anna Lindstrand^{39

40}, Tuuli Lappalainen^{41

42}

Affiliations

¹ Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
² Department of Clinical Genetics and Genomics, Karolinska University Hospital, Stockholm, Sweden.
³ Department of Gene Technology, SciLifeLab, KTH Royal Institute of Technology, Stockholm, Sweden.
⁴ Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
⁵ Clinical Genomics, SciLifeLab, Linköping, Sweden.
⁶ Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
⁷ Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.
⁸ SciLifeLab, Uppsala University, Uppsala, Sweden.
⁹ Broad Institute of MIT and Harvard, Cambridge, MA, USA.
¹⁰ Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
¹¹ Department of Clinical Genetics, Pathology and Molecular Diagnostics, Skåne University Hospital, Lund, Sweden.
¹² Division of Pathology, Department of Clinical Sciences, Lund University, Lund, Sweden.
¹³ Division of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden.
¹⁴ Clinical Genomics, SciLifeLab, Lund, Sweden.
¹⁵ Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
¹⁶ Department of Clinical Sciences, Lund University, Helsingborg, Sweden.
¹⁷ Precision Health University Research Institute, Queen Mary University of London, London, UK.
¹⁸ The Swedish Network Against Cancer, Stockholm, Sweden.
¹⁹ Department of Cell and Molecular Biology, NBIS, SciLifeLab, Uppsala University, Uppsala, Sweden.
²⁰ Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.
²¹ Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
²² Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.
²³ Department of Diagnostics and Intervention, Oncology, Umeå University, Umeå, Sweden.
²⁴ Medical Epidemiology, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
²⁵ Department of Clinical Genetics and Genomics, Sahlgrenska University Hospital, Gothenburg, Sweden.
²⁶ Department of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
²⁷ Division of Oncology, Department of Clinical Sciences, Lund University, Lund, Sweden.
²⁸ Department of Protein Science, SciLifeLab, KTH Royal Institute of Technology, Stockholm, Sweden.
²⁹ Bioinformatics and Data Centre, University of Gothenburg, Gothenburg, Sweden.
³⁰ The George Institute for Global Health, University of New South Wales, Sydney, New South Wales, Australia.
³¹ Wallenberg Centre for Molecular Medicine, Umeå University, Umeå, Sweden.
³² Centre for Inherited Metabolic Diseases, Karolinska University Hospital, Stockholm, Sweden.
³³ Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
³⁴ Department of Obstetrics and Gynecology, University of Gothenburg, Gothenburg, Sweden.
³⁵ Department of Obstetrics and Gynecology, Sahlgrenska University Hospital, Western Health Care Region, Gothenburg, Sweden.
³⁶ Department of Genetics and Bioinformatics, Division of Health Data and Digitalisation, Institute of Public Health, Oslo, Norway.
³⁷ Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden. richard.rosenquist@ki.se.
³⁸ Department of Clinical Genetics and Genomics, Karolinska University Hospital, Stockholm, Sweden. richard.rosenquist@ki.se.
³⁹ Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden. anna.lindstrand@ki.se.
⁴⁰ Department of Clinical Genetics and Genomics, Karolinska University Hospital, Stockholm, Sweden. anna.lindstrand@ki.se.
⁴¹ Department of Gene Technology, SciLifeLab, KTH Royal Institute of Technology, Stockholm, Sweden. tuuli.lappalainen@scilifelab.se.
⁴² New York Genome Center, New York, NY, USA. tuuli.lappalainen@scilifelab.se.

PMID: 40186080
DOI: 10.1038/s41591-025-03631-9

Precision Omics Initiative Sweden (PROMISE) will integrate research with healthcare

Anders Kämpe et al. Nat Med. 2025 Jun.

. 2025 Jun;31(6):1730-1732.

doi: 10.1038/s41591-025-03631-9.

Authors

Affiliations

¹ Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
² Department of Clinical Genetics and Genomics, Karolinska University Hospital, Stockholm, Sweden.
³ Department of Gene Technology, SciLifeLab, KTH Royal Institute of Technology, Stockholm, Sweden.
⁴ Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
⁵ Clinical Genomics, SciLifeLab, Linköping, Sweden.
⁶ Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
⁷ Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.
⁸ SciLifeLab, Uppsala University, Uppsala, Sweden.
⁹ Broad Institute of MIT and Harvard, Cambridge, MA, USA.
¹⁰ Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
¹¹ Department of Clinical Genetics, Pathology and Molecular Diagnostics, Skåne University Hospital, Lund, Sweden.
¹² Division of Pathology, Department of Clinical Sciences, Lund University, Lund, Sweden.
¹³ Division of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden.
¹⁴ Clinical Genomics, SciLifeLab, Lund, Sweden.
¹⁵ Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
¹⁶ Department of Clinical Sciences, Lund University, Helsingborg, Sweden.
¹⁷ Precision Health University Research Institute, Queen Mary University of London, London, UK.
¹⁸ The Swedish Network Against Cancer, Stockholm, Sweden.
¹⁹ Department of Cell and Molecular Biology, NBIS, SciLifeLab, Uppsala University, Uppsala, Sweden.
²⁰ Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.
²¹ Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
²² Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.
²³ Department of Diagnostics and Intervention, Oncology, Umeå University, Umeå, Sweden.
²⁴ Medical Epidemiology, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
²⁵ Department of Clinical Genetics and Genomics, Sahlgrenska University Hospital, Gothenburg, Sweden.
²⁶ Department of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
²⁷ Division of Oncology, Department of Clinical Sciences, Lund University, Lund, Sweden.
²⁸ Department of Protein Science, SciLifeLab, KTH Royal Institute of Technology, Stockholm, Sweden.
²⁹ Bioinformatics and Data Centre, University of Gothenburg, Gothenburg, Sweden.
³⁰ The George Institute for Global Health, University of New South Wales, Sydney, New South Wales, Australia.
³¹ Wallenberg Centre for Molecular Medicine, Umeå University, Umeå, Sweden.
³² Centre for Inherited Metabolic Diseases, Karolinska University Hospital, Stockholm, Sweden.
³³ Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
³⁴ Department of Obstetrics and Gynecology, University of Gothenburg, Gothenburg, Sweden.
³⁵ Department of Obstetrics and Gynecology, Sahlgrenska University Hospital, Western Health Care Region, Gothenburg, Sweden.
³⁶ Department of Genetics and Bioinformatics, Division of Health Data and Digitalisation, Institute of Public Health, Oslo, Norway.
³⁷ Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden. richard.rosenquist@ki.se.
³⁸ Department of Clinical Genetics and Genomics, Karolinska University Hospital, Stockholm, Sweden. richard.rosenquist@ki.se.
³⁹ Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden. anna.lindstrand@ki.se.
⁴⁰ Department of Clinical Genetics and Genomics, Karolinska University Hospital, Stockholm, Sweden. anna.lindstrand@ki.se.
⁴¹ Department of Gene Technology, SciLifeLab, KTH Royal Institute of Technology, Stockholm, Sweden. tuuli.lappalainen@scilifelab.se.
⁴² New York Genome Center, New York, NY, USA. tuuli.lappalainen@scilifelab.se.

PMID: 40186080
DOI: 10.1038/s41591-025-03631-9

No abstract available

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Conflict of interest statement

Competing interests: T.F. is co-founder, board member and scientific advisor to Qlucore and Lead Biologics and co-founder and scientific advisor to Cantargia. P.F. is a paid member of advisory boards for Novo Nordisk, Sidra Health, Zoe and ABC Labs; has received research funding (paid to institution) from numerous pharmaceutical companies as part of the Innovative Medicines Initiative of the European Union; and is co-chair of the Precision Medicine in Diabetes Initiative and the US National Institute of Diabetes and Digestive and Kidney Diseases Working Group of Council on Heterogeneity in Diabetes. L.S. is co-founder and shareholder of SAGA Diagnostics and advisor to DoMore Diagnostics and has received honoraria from AstraZeneca. J.S. has conducted contract research (paid to institution) for Capitainer and Luminex and has received speaker/travel fees from Roche Diagnostics, Olink and Luminex. E.M. has received advisory board or lecture honoraria from ALK, AstraZeneca, Chiesi and Sanofi. J.S. has direct or indirect stock ownership in companies (Anagram kommunikation, Sence Research, Symptoms Europe and MinForskning) providing services to companies and authorities in the health sector, including Amgen, AstraZeneca, Bayer, Boehringer, Eli Lilly, Gilead, GSK, Göteborg University, Itrim, Ipsen, Janssen, Karolinska Institutet, LIF, Linköping University, Novo Nordisk, Parexel, Pfizer, Region Stockholm, Region Uppsala, Sanofi, STRAMA, Takeda, TLV, Uppsala University, Vifor Pharma and WeMind. B.V.G. has received speaker honoraria from AstraZeneca. T.S. is co-founder, shareholder and board member of Oncodia. R.R. has received honoraria from AbbVie, AstraZeneca, Illumina, Janssen, Lilly and Roche. A.L. has received speaker honoraria from Illumina and Pacific Biosciences. T.L. is a scientific advisor to and has equity in Variant Bio and has received speaker honoraria from Abbvie and Merck.

References

1. Kämpe, A. et al. Preprint at SSRN https://doi.org/10.2139/ssrn.4992987 (2024).
1. Uhlén, M. et al. Science 347, 1260419 (2015). - DOI - PubMed
1. Government Offices of Sweden. Regerinskansliet https://go.nature.com/4hrlIaV (7 November 2024).
1. Fioretos, T. et al. Nat. Med. 28, 1980–1982 (2022). - DOI - PubMed
1. Bergström, G. et al. J. Intern. Med. 278, 645–659 (2015). - DOI - PubMed - PMC

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Precision Omics Initiative Sweden (PROMISE) will integrate research with healthcare

Affiliations

Precision Omics Initiative Sweden (PROMISE) will integrate research with healthcare

Authors

Affiliations

Conflict of interest statement

References

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LinkOut - more resources

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