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. 1985 Apr;36(4):318-9.
doi: 10.1016/0020-708x(85)90094-8.

Synthesis and some characteristics of no-carrier added [18F]fluorotrimethylsilane

M S Rosenthal, A L Bosch, R J Nickles, S J Gatley

Synthesis and some characteristics of no-carrier added [18F]fluorotrimethylsilane

M S Rosenthal et al. Int J Appl Radiat Isot. 1985 Apr.

Abstract

[18F]Fluorotrimethylsilane was prepared in 80% decay corrected yield by reaction of no-carrier added tetramethyl-ammonium fluoride (hydroxide as bulk anion) with chlorotrimethylsilane in 65% aqueous acetonitrile. The 18F gas was collected in a cold-trap at -130 degrees C and found to have an Ostwald solubility coefficient of 11.5 in paraffin oil. Accurate measurement of its aqueous solubility was precluded by hydrolysis. When rats were allowed to inhale [18F]fluorotrimethylsilane extensive uptake of 18F occurred in bone, demonstrating ready release of fluoride in vivo.

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