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. 1985 Jun;23(6):288-90.

The localization of antibiotics by continuous sucrose gradient density

K Fujita, H M Fujita
  • PMID: 4018926

The localization of antibiotics by continuous sucrose gradient density

K Fujita et al. Int J Clin Pharmacol Ther Toxicol. 1985 Jun.

Abstract

Rat kidney was homogenized and centrifuged by continuous sucrose gradient density. Aminoglycosides and beta-lactam antibiotics were localized in the lysosomes, whereas the localization of tetracyclines was in the mitochondria. This study demonstrated a technique for the localization of antibiotics in the subcellular fractions without the use of a radioactive tracer.

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