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. 2025 Apr 1:13:e19165.
doi: 10.7717/peerj.19165. eCollection 2025.

A cross-sectional study on the effects of bedtime administration of selective α1 adrenoceptor antagonists on nocturnal blood pressure in elderly patients with benign prostate hyperplasia

Chao-Ting Chen #  1 , Shao-Jun Ma #  1 , Hai-Ya Wang  1 , Hai-Jun Yao  2
Affiliations

A cross-sectional study on the effects of bedtime administration of selective α1 adrenoceptor antagonists on nocturnal blood pressure in elderly patients with benign prostate hyperplasia

Chao-Ting Chen et al. PeerJ. .

Abstract

Background: It remains uncertain whether a bedtime dose of selective α1 adrenoceptor antagonist could result in nocturnal hypotension in elderly patients with benign prostate hyperplasia (BPH).

Methods: A total of 253 older men with BPH who had taken selective α1 adrenoceptor antagonists before sleep were consecutively recruited from the Geriatric Department of Shanghai Ninth People's Hospital. A total of 221 patients were finally included in the analysis with qualified data including office blood pressure examinations, biochemical tests of blood, and 24-hour ambulatory blood pressure monitoring. Nocturnal hypotension was defined according to the nighttime average systolic blood pressure of ambulatory blood pressure ≤ 100 mmHg and/or diastolic blood pressure ≤ 60 mmHg. Explore the presence of night hypotension, compare the characteristics of the two groups with or without nocturnal hypotension, and analyze the related risk factors.

Results: Among all 221 patients included in the analysis, nocturnal hypotension occurred in 38 patients (17.2%). Compared with those without, patients with nocturnal hypotension were older, had less body mass index, lower office diastolic blood pressure, and lower ambulatory blood pressure in a 24 hour day, and night systolic and diastolic blood pressure, and were less likely to have hypertension. Age (OR 1.064, 95% CI [1.012-1.118], P = 0.015) and no hypertension (OR 2.548, 95% CI [1.211-5.359], P = 0.014) were independently associated with the presence of nocturnal hypotension.

Discussion: Nocturnal hypotension was common in men 60 years and older with BPH treated with selective α1 adrenoceptor antagonists before sleep. Age and no hypertension were independently associated with nocturnal hypotension positively. Related factors may help clinicians identify hypotension tendencies in the elderly when prescribing such drugs.

Keywords: Adrenergic alpha-1 receptor antagonist; Ambulatory blood pressure monitoring; Geriatric medicine; Nocturnal hypotension; The elderly.

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Conflict of interest statement

The authors declare there are no competing interests.

Figures

Figure 1
Figure 1. Association of nocturnal hypotension distribution with age (A) and hypertension (B) in 221 older men with prostate hyperplasia given a bedtime dose of selective α1 adrenoceptor antagonists.
Figure 2
Figure 2. Multivariate joint prediction ROC curve (A) and logistic plots of age (B), office DBP (C), and BMI (D) for nocturnal hypotension.
Figure 3
Figure 3. ROC curve analysis for age, BMI, and DBPo (ROC, receiver operating characteristic; AUC, Area under the ROC curve; BMI indicates body mass index; DBPo stands for office diastolic blood pressure.
See this image and copyright information in PMC

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