Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2025 May 14;31(27):e202500756.
doi: 10.1002/chem.202500756. Epub 2025 Apr 21.

Supramolecular Matter Through Crystal Engineering: Covalent Bond Formation to Postsynthetic Modification

Changan Li  1 , Leonard R MacGillivray  2
Affiliations
Review

Supramolecular Matter Through Crystal Engineering: Covalent Bond Formation to Postsynthetic Modification

Changan Li et al. Chemistry. .

Abstract

Supramolecular chemistry can transform organic synthesis by revealing that crystalline materials are not static but rather dynamic environments for controlled covalent bond formations and manipulations. This review focuses on how supramolecular chemistry can be developed to direct molecular synthesis in the organic solid state, directing reliable C─C bond formations to enable transformations difficult or impossible in solution. Special attention is given to postsynthetic modifications that serve to broaden the functional scope of solid-state reactivity allowing organic crystals to be developed as molecular flasks and a form of supramolecular matter.

Keywords: crystal engineering; post‐modification; solid‐state chemistry; supramolecular chemistry.

PubMed Disclaimer

References

    1. J. D. Dunitz, V. Schomaker, K. N. Trueblood, J. Phys. Chem. 1988, 92, 856.
    1. G. R. Desiraju, Angew. Chem., Int. Ed. 2007, 46, 8342.
    1. K. Biradha, R. Santra, Chem. Soc. Rev. 2013, 42, 950.
    1. L. R. MacGillivray, G. S. Papaefstathiou, T. Friščić, T. D. Hamilton, D.‐K. Bučar, Q. Chu, D. B. Varshney, I. G. Georgiev, Acc. Chem. Res. 2008, 41, 280.
    1. D. Braga, F. Grepioni, Angew. Chem., Int. Ed. 2004, 43, 4002.

LinkOut - more resources