Review
doi: 10.1038/265299a0.
Molecular analysis of spontaneous somatic mutants
- PMID: 401950
- DOI: 10.1038/265299a0
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Review
Molecular analysis of spontaneous somatic mutants
Nature.
.
Abstract
Eukaryotic structural gene mutations occurring spontaneously in a mouse myeloma cell line offer the opportunity to study somatic mutation in animal cells at the molecular level. Studies on the myeloma protein and on mRNA have enabled us to characterise four such mutants representing four different mutation mechanisms. The results may have some bearing on the origin of antibody diversity.
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