HIV-exposed uninfected umbilical cord blood haematopoietic stem/progenitor cells differ immunophenotypically from those from HIV unexposed umbilical cord blood but have similar expansion and colony-forming properties in vitro
- PMID: 40195551
- DOI: 10.1038/s41409-025-02574-6
HIV-exposed uninfected umbilical cord blood haematopoietic stem/progenitor cells differ immunophenotypically from those from HIV unexposed umbilical cord blood but have similar expansion and colony-forming properties in vitro
Conflict of interest statement
Competing interests: MSP has received research grants from the South African Medical Research Council, the Bill and Melinda Gates Foundation, the South African National Health Laboratory Service Research Trust, The National Research Foundation (South Africa) and the Wellcome Trust. MSP is a co-founder and non-remunerated board member of Antion Biosciences and Altera Biosciences and is also CSO of the latter. CLH is a non-remunerated board member of DKMS Africa, a not-for-profit organisation. Ethics approval: Ethics approval for this work was obtained from the University of Pretoria Faculty of Health Sciences Research Ethics Committee, approval number 102/2020. All enrolled mothers gave written informed consent, for collection of umbilical cord blood after delivery of the infant, for the purposes of the study. All methods were performed in accordance with the relevant guidelines and regulations.
References
-
- Viljoen IM, Hendricks CL, Mellet J, Pepper MS. Perspectives on establishing a public cord blood inventory in South Africa. Cytotherapy. 2021;23:548–57. https://www.isct-cytotherapy.org/article/S1465-3249(21)00172-9/abstract - DOI - PubMed
-
- Sanchez-Petitto G, Rezvani K, Daher M, Rafei H, Kebriaei P, Shpall EJ, et al. Umbilical Cord Blood Transplantation: Connecting Its Origin to Its Future. Stem Cells Transl Med. 2023;12:55–71. https://doi.org/10.1093/stcltm/szac086 - DOI - PubMed - PMC
-
- Spellman SR. Hematology 2022 — what is complete HLA match in 2022? Am Soc Haematol Educ Program [Internet]. 2022;1:83–9. Dec 9 [cited 2025 Jan 17]Available from: https://doi.org/10.1182/hematology.2022000326
-
- Dumont-Lagacé M, Feghaly A, Meunier MC, Finney M, Van’t Hof W, Masson Frenet E, et al. UM171 Expansion of Cord Blood Improves Donor Availability and HLA Matching For All Patients. Including Minorities. Transpl Cell Ther [Internet]. 2022;28:410.e1–410.e5. https://www.sciencedirect.com/science/article/pii/S2666636722011642?via%...
-
- Goga A, Chirinda W, Ngandu NK, Ngoma K, Bhardwaj S, Feucht U, et al. Closing the gaps to eliminate mother-to-child transmission of HIV (MTCT) in South Africa: Understanding MTCT case rates, factors that hinder the monitoring and attainment of targets, and potential game changers. South Afr Med J [Internet]. 2018;108:17 https://www.scienceopen.com/document?vid=942b87cd-2bab-4b25-a73e-ba41470... - DOI
Publication types
Grants and funding
LinkOut - more resources
Full Text Sources
