Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2025 Apr 7;38(2):74-76.
doi: 10.54847/cp.2025.02.17.

Gastrointestinal stromal tumor surgery in pediatrics

[Article in English, Spanish]
S D Israel  1 , A Del Cañizo  1 , S Monje  1 , M Sáenz  1 , J Bueno  1 , J Ordóñez  1 , L Pérez Egido  1 , M A García Casillas  1 , J A Cerdá  1 , I Bada Bosch  2 , M Fanjul  1 , D Peláez  1 , J C de Agustín  1
Affiliations
Free article
Case Reports

Gastrointestinal stromal tumor surgery in pediatrics

[Article in English, Spanish]
S D Israel et al. Cir Pediatr. .
Free article

Abstract
in English, Spanish

Introduction: Gastrointestinal stromal tumors (GIST) are infrequent in pediatric patients. The management of metastatic and irresectable tumors is usually non-surgical, with tyrosine-kinase inhibitors being the treatment of choice.

Clinical case: We present the case of a 14-year-old female patient with a metastatic and irresectable GIST treated with sunitinib that required surgery as a result of severe hemoperitoneum episodes with anemia and hemodynamic instability. A cytoreductive surgery with R2 resection margins was carried out. After a 10-year follow-up period, the patient remains under oncological treatment.

Discussion: The treatment of metastatic and irresectable GIST consists of tyrosine-kinase inhibitors. Evidence regarding the role of surgery remains limited, which means extreme caution should be exerted when indicating surgical treatment. However, surgery is still a useful tool within the array of therapeutic options.

Introduccion: Los tumores del estroma gastrointestinal (GIST) son tumores infrecuentes en la edad pediátrica. El manejo de los tumores metastásicos e irresecables no suele ser quirúrgico, siendo de elección el uso de inhibidores de tirosin-kinasas.

Caso clinico: Se presenta el caso de una paciente de 14 años con un tumor GIST metastásico e irresecable en tratamiento con sunitinib que precisó una intervención quirúrgica por episodios de hemoperitoneo grave con anemización e inestabilidad hemodinámica. Se realizó una cirugía de citorreducción con márgenes de resección R2 previstos. Tras 10 años de seguimiento la paciente continúa en tratamiento oncológico.

Comentarios: El tratamiento de los tumores GIST metastásicos e inoperables lo constituyen el uso de inhibidores de tirosin-kinasa. El papel de la cirugía sigue siendo un área con evidencia limitada, por lo que esta debe indicarse con extrema precaución; sin embargo, esta sigue siendo una herramienta valiosa dentro del arsenal terapéutico.

Keywords: Gastrointestinal stromal tumors; Pediatrics; Surgical oncology.

PubMed Disclaimer

Publication types

MeSH terms

LinkOut - more resources