Arterial pressure- and cardiac rhythm-related single-neuron activities in the nucleus reticularis gigantocellularis of the rat

Abstract

This communication presents an analysis of 531 extracellularly recorded spontaneously active nucleus reticularis gigantocellularis (NRGC) single-neurons in pentobarbital anesthetized rats, with particular reference to their cardiovascular-related activities. Fifty-nine percent of the gigantocellular neurons evaluated had temporal relationship with induced or spontaneous arterial pressure fluctuations. Twenty-eight percent of the NRGC neurons manifested definite discharge patterns and periodicity with reference to the cardiac cycle. It is discussed that these gigantocellular neurons may serve as a primary component of the cardiovascular regulatory mechanism. Alternatively, they may coordinate the necessary circulatory support for activities varying from respiration to somatomotor functions or sleep-wakefulness.