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Review
. 2025 Jan 16;12(1):e99010049.
doi: 10.14440/jbm.2025.0094. eCollection 2025.

Lipidomics and temporal-spatial distribution of organelle lipid

Wenjuan Qian  1 , Huiru Tang  1 , Hongyan Yao  1
Affiliations
Review

Lipidomics and temporal-spatial distribution of organelle lipid

Wenjuan Qian et al. J Biol Methods. .

Abstract

Background: Lipids are crucial signaling molecules or cellular membrane components orchestrating biological processes. To gain insights into lipid functions and the communication between organelles, it is essential to understand the subcellular localization of individual lipids. Advancements in lipid quantification techniques, improvements in chemical and spatial resolution for detecting various lipid species, and enhancements in organelle isolation speed have allowed for profiling of the organelle lipidome, capturing its temporal-spatial distribution.

Objective: This review examined approaches used to develop organelle lipidome and aimed to gain insights into cellular lipid homeostasis from an organelle perspective. In addition, this review discussed the advancements in lipid-mediated inter-organelle communication within complex physiological and pathological processes.

Conclusion: With the advancement of lipidomic technologies, more detailed explorations of organelle structures and the specific lipid-mediating functions they perform are feasible.

Keywords: Cellular lipid homeostasis; Inter-organelle communication; Lipidomics; Organelle isolation; Organelle lipid distribution.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Distribution of organellar lipids in macrophages. Abbreviations: ER: Endoplasmic reticulum; Golgi: Golgi complex; LD: Lipid droplet; Lyso: Lysosome; Mito: Mitochondria; Nuc: Nucleus; Pero: Peroxisome; PM: Plasma membrane.
Figure 2
Figure 2
The lipid distribution of organelles in cancer metastasis. An overview highlighting some of the organelles that are involved in lipid metabolism during cancer metastasis (inner ring) and organellar lipids that may specifically enrich (outer ring). Abbreviations: CE: Cholesteryl ester; DAG: Diacylglycerol; PE: Phosphatidylethanolamine; PIP: Phosphoinositide; PUFA: Polyunsaturated fatty acid; S1P: Sphingosine-1-phosphate; TAG: Triacylglycerol.
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