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. 2025 Mar 25:19:1424629.
doi: 10.3389/fnins.2025.1424629. eCollection 2025.

Use of nasal mucosal autonomic nerve response in efficacy evaluation of vidian neurectomy for allergic rhinitis: a prospective study

Linzheng Liu #  1 , Na Ma #  1 , Yan Niu  1 , Yuping Peng  1 , Yan Li  1 , Jiangjiang Shen  1 , Jiameng He  2 , Jindi Sun  2
Affiliations

Use of nasal mucosal autonomic nerve response in efficacy evaluation of vidian neurectomy for allergic rhinitis: a prospective study

Linzheng Liu et al. Front Neurosci. .

Abstract

Objective: To evaluate the use of nasal mucosal autonomic nerve responses as an objective indicator for assessing the efficacy of vidian neurectomy (VN) in treating allergic rhinitis (AR).

Methods: Thirty-five patients with moderate to severe AR and 35 healthy controls were included. Autonomic nerve responses were measured before and 1 month after VN surgery, using respiratory stimulation on the nasal mucosa and the opisthenar area. Three waveform types (P-type, N-type and M-type) were identified.

Results: While three waveform types were identified in the nasal mucosa, only the M-type was observed in the opisthenar sympathetic skin response. Preoperative measurements showed higher autonomic responses in patients with AR compared with controls. Following VN, the responses in patients with AR decreased significantly, aligning closely with the control group. No significant changes were observed in the opisthenar responses, indicating a localised effect of VN. Comorbidities such as nasal polyps, sinusitis and deviated septum did not impact the results.

Conclusion: Nasal mucosal autonomic nerve response provides a reliable, objective measure for evaluating the effectiveness of VN in treating AR.

Keywords: allergic rhinitis; nasal mucosal autonomic nerve response; sympathetic skin response; vidian nerve; waveform.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
The flow diagram chart for this study.
Figure 2
Figure 2
Waveforms of nasal autonomous nerve response and SSR (A) P-type of nasal autonomous nerve response. (B) N-type of nasal autonomous nerve response. (C) M-type of nasal autonomous nerve response. (D) M-type of SSR.
See this image and copyright information in PMC

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