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Case Reports
. 2025 Mar 15:60:103011.
doi: 10.1016/j.eucr.2025.103011. eCollection 2025 May.

Renin-secreting chromophobe renal cell carcinoma: An uncommon cause of secondary hypertension in a young female

Tareq Jarrar  1 , Younes Jafar Hamam  2 , Hadeel Abdallah Al Kayed  3 , Bassel Esmat Alrabadi  4 , Ayham Kamel Milhem  5 , Maryam Hisham Alqatawna  6 , Husam Odaibat  6
Affiliations
Case Reports

Renin-secreting chromophobe renal cell carcinoma: An uncommon cause of secondary hypertension in a young female

Tareq Jarrar et al. Urol Case Rep. .

Abstract

Renal cell carcinoma (RCC) is a rare but significant cause of secondary hypertension. Chromophobe RCC represents 5 % of all RCC cases, with renin secretion being even rarer. We report a case of a 32-year-old female with six-month history of uncontrolled hypertension. Laboratory findings showed elevated plasma renin and aldosterone levels. Imaging revealed a large left renal mass. After radical nephrectomy, histopathology confirmed chromophobe RCC. Her blood pressure normalized postoperatively, and she was normotensive at 1-month follow-up. This case underscores the importance of considering renal tumors in hypertensive patients and the role of surgery in achieving favorable outcomes.

Keywords: Chromophobe RCC; Paraneoplastic syndrome; Renal cell carcinoma (RCC); Renin-secreting tumor; Secondary hypertension; Uncontrolled hypertension.

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Conflict of interest statement

The authors declare no conflicts of interest related to this publication.

Figures

Fig. 1
Fig. 1
Schematic representation of the most prevalent subtypes of renal cell carcinoma (RCC).
Fig. 2
Fig. 2
Contrast-enhanced computed tomography (CT) scan demonstrating a well-defined, mildly enhancing mass measuring 93 × 92 × 96 mm located in the upper pole of the left kidney (red arrow).
Fig. 3
Fig. 3
A gross image of the resected specimen showed a large mass measuring about 9 × 9 × 9 cm.
See this image and copyright information in PMC

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