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. 2025 Mar 1;5(2):100471.
doi: 10.1016/j.xagr.2025.100471. eCollection 2025 May.

Hypertensive pregnancy deaths: a three-year review at Ghana's largest referral hospital

Theodore K Boafor  1 , Perez Sepenu  2 , Ama Tamatey  1 , Promise Sefogah  1 , Alim Swarray-Deen  1 , Naa Akushia Sepenu  3 , Kwadwo Asiedu  2 , Joshua Waliu Kamal  2 , Winfred K Baah  4 , Emma Lawrence  5 , Jerry Coleman  2
Affiliations

Hypertensive pregnancy deaths: a three-year review at Ghana's largest referral hospital

Theodore K Boafor et al. AJOG Glob Rep. .

Abstract

Background: Maternal mortality continues to be a significant public health challenge in sub-Saharan Africa. Even though the leading causes, such as hypertensive disorders in pregnancy and obstetric hemorrhage have remained unchanged, associated factors continue to significantly impact reduction efforts in the maternal mortality ratio. Despite efforts, Ghana's maternal mortality ratio has not significantly decreased since 2015, the end of the Millennium Development Goals (MDGs). To achieve Sustainable Development Goal (SDG) targets, it is essential to understand and focus on reducing deaths from leading causes such as hypertensive disorders of pregnancy and emerging associated factors that contribute to maternal mortality.

Objective: This study aimed to examine the contributors to maternal deaths related to hypertensive disorders at Korle Bu Teaching Hospital, Accra, Ghana.

Study design: The study was a hospital-based retrospective review of 162 audited maternal deaths occurring at the Korle Bu Teaching Hospital from January 2021 to December 2023. Data was collected using a review of medical records and clinical notes of maternal deaths as well as maternal death audit reports. The direct and indirect causes of death were analyzed, with a focus on hypertensive disorders in pregnancy. Data on socio-demographic characteristics, parity, referral status, and length of hospital stay were extracted. Maternal mortality ratio and case fatality rates were calculated. Statistical analyses were conducted to compare hypertensive-related deaths with nonhypertensive maternal deaths.

Results: Hypertensive disorders in pregnancy accounted for 40.7% of all audited maternal deaths, decreasing from 52.2% in 2021 to 30.5% in 2023. Women aged 30 to 34 years had the highest number of deaths, while women over 45 had the highest maternal mortality ratio (1754.4 per 100,000 live births). Case fatality rates for hypertensive disorders decreased from 2.4% in 2021 to 1.5% in 2023. Lower parity (≤2) was associated with significantly higher mortality. Most women (77.3%) who died from hypertensive disorders were referred from other facilities. Length of hospital stay varied, with a majority of 40.9% staying seven or more days before death. The top four immediate causes of hypertensive-related maternal deaths were Eclampsia (43.9%), HELLP Syndrome (22.7%), Acute Kidney Injury (12.2%) and Pulmonary edema (9.1%).

Conclusion: Hypertensive disorders are a major cause of maternal mortality at Korle Bu Teaching Hospital. Despite declining case fatality rates, the burden of hypertensive-related deaths remains significant. Improved antenatal care, efficient referral systems, and better emergency obstetric care are essential to reducing maternal mortality.

Keywords: Ghana; Korle Bu teaching hospital; Sub-Saharan Africa; antenatal care; case fatality rate; hypertensive disorders; maternal mortality; pregnancy.

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Figures

Figure 1
Figure 1
Trend of yearly case fatality rate and maternal mortality ratio of audited hypertensive related deaths in Korle Bu teaching hospital, Accra, Ghana, from 2021 to 2023
Figure 2
Figure 2
Age distribution based maternal mortality ratio related to audited deaths from hypertensive disorders at Korle Bu teaching hospital, Accra, Ghana, from 2021 to 2023
Figure 3
Figure 3
Parity distribution based maternal mortality ratio related to audited deaths from hypertensive disorders at Korle Bu teaching hospital, Accra, Ghana, from 2021 to 2023
Figure 4
Figure 4
Length of hospital stay of women who died from a hypertensive disorder of pregnancy at Korle Bu teaching hospital, Accra, Ghana, from 2021 to 2023
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