Grand Challenges on HIV/AIDS in China - The 5th Symposium, Yunnan 2024

doi:10.1080/22221751.2025.2492208

. 2025 Dec;14(1):2492208.

doi: 10.1080/22221751.2025.2492208. Epub 2025 Apr 22.

Grand Challenges on HIV/AIDS in China - The 5th Symposium, Yunnan 2024

Zhiwei Chen^{1

2

3}, Jianqing Xu⁴, Xia Jin⁵, Jianhua Wang⁶, Jinghe Huang⁷, Hui Zhang⁸, Ling Chen^{6

9}, Kai Deng^{10

11

12}, Weiping Cai¹³, Linghua Li¹³, Fusheng Wang^{14

15}, Zhiwei Wu¹⁶, Hong Shang¹⁷, Hao Wu¹⁸; and the GCC Scientists

Collaborators, Affiliations

Collaborators

and the GCC Scientists:
Linqi Zhang

Affiliations

¹ AIDS Institute and Department of Microbiology, State Key Laboratory of Emerging Infectious Diseases, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, People's Republic of China.
² Center for Virology, Vaccinology and Therapeutics, Hong Kong Science and Technology Park, Hong Kong, People's Republic of China.
³ Pandemic Research Alliance Unit at The University of Hong Kong, Pokfulam, People's Republic of China.
⁴ Clinical Center of Biotherapy at Zhongshan Hospital & Institutes of Biomedical Sciences, Shanghai Institute of Infectious Disease and Biosecurity, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People's Republic of China.
⁵ Shanghai Public Health Clinical Center, Fudan University, Shanghai, People's Republic of China.
⁶ Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, People's Republic of China.
⁷ Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS) and Shanghai Institute of Infectious Disease and Biosecurity, Shanghai Public Health Clinical Center, Shanghai Fifth People's Hospital, Institutes of Biomedical Sciences, School of Basic Medical Sciences, Fudan University, Shanghai, People's Republic of China.
⁸ Institute of Human Virology, Department of Pathogen Biology and Biosecurity, Key Laboratory of Tropical Disease Control of Ministry Education, Guangdong Engineering Research Center for Antimicrobial Agent and Immunotechnology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, People's Republic of China.
⁹ Guangzhou National Laboratory, Guangzhou International Bio-Island, Guangzhou, People's Republic of China.
¹⁰ Institute of Human Virology, Key Laboratory of Tropical Disease Control of Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, People's Republic of China.
¹¹ Department of Immunology and Microbiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, People's Republic of China.
¹² Advanced Medical Technology Center, The First Affiliated Hospital, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, People's Republic of China.
¹³ Infectious Disease Center, Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.
¹⁴ Senior Department of Infectious Diseases, The Fifth Medical Center of PLA General Hospital, National Clinical Research Center for Infectious Diseases, Beijing, People's Republic of China.
¹⁵ Medical School of Chinese PLA, Beijing, People's Republic of China.
¹⁶ Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical R&D, College of Pharmacy, Dali University, Dali, People's Republic of China.
¹⁷ State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, NHC Key Laboratory of AIDS Prevention and Treatment, National Clinical Research Center for Laboratory Medicine, The First Hospital of China Medical University, China Medical University, Shenyang, People's Republic of China.
¹⁸ Clinical and Research Center for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, Beijing, People's Republic of China.

PMID: 40202047
PMCID: PMC12016243
DOI: 10.1080/22221751.2025.2492208

Grand Challenges on HIV/AIDS in China - The 5th Symposium, Yunnan 2024

Zhiwei Chen et al. Emerg Microbes Infect. 2025 Dec.

. 2025 Dec;14(1):2492208.

doi: 10.1080/22221751.2025.2492208. Epub 2025 Apr 22.

Authors

Collaborators

and the GCC Scientists:
Linqi Zhang

Affiliations

¹ AIDS Institute and Department of Microbiology, State Key Laboratory of Emerging Infectious Diseases, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, People's Republic of China.
² Center for Virology, Vaccinology and Therapeutics, Hong Kong Science and Technology Park, Hong Kong, People's Republic of China.
³ Pandemic Research Alliance Unit at The University of Hong Kong, Pokfulam, People's Republic of China.
⁴ Clinical Center of Biotherapy at Zhongshan Hospital & Institutes of Biomedical Sciences, Shanghai Institute of Infectious Disease and Biosecurity, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People's Republic of China.
⁵ Shanghai Public Health Clinical Center, Fudan University, Shanghai, People's Republic of China.
⁶ Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, People's Republic of China.
⁷ Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS) and Shanghai Institute of Infectious Disease and Biosecurity, Shanghai Public Health Clinical Center, Shanghai Fifth People's Hospital, Institutes of Biomedical Sciences, School of Basic Medical Sciences, Fudan University, Shanghai, People's Republic of China.
⁸ Institute of Human Virology, Department of Pathogen Biology and Biosecurity, Key Laboratory of Tropical Disease Control of Ministry Education, Guangdong Engineering Research Center for Antimicrobial Agent and Immunotechnology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, People's Republic of China.
⁹ Guangzhou National Laboratory, Guangzhou International Bio-Island, Guangzhou, People's Republic of China.
¹⁰ Institute of Human Virology, Key Laboratory of Tropical Disease Control of Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, People's Republic of China.
¹¹ Department of Immunology and Microbiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, People's Republic of China.
¹² Advanced Medical Technology Center, The First Affiliated Hospital, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, People's Republic of China.
¹³ Infectious Disease Center, Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.
¹⁴ Senior Department of Infectious Diseases, The Fifth Medical Center of PLA General Hospital, National Clinical Research Center for Infectious Diseases, Beijing, People's Republic of China.
¹⁵ Medical School of Chinese PLA, Beijing, People's Republic of China.
¹⁶ Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical R&D, College of Pharmacy, Dali University, Dali, People's Republic of China.
¹⁷ State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, NHC Key Laboratory of AIDS Prevention and Treatment, National Clinical Research Center for Laboratory Medicine, The First Hospital of China Medical University, China Medical University, Shenyang, People's Republic of China.
¹⁸ Clinical and Research Center for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, Beijing, People's Republic of China.

PMID: 40202047
PMCID: PMC12016243
DOI: 10.1080/22221751.2025.2492208

Abstract

HIV-1 infection has led to 1.329 million people living with the virus and 0.474 millions of deaths by the middle of 2024 in China. Achieving the goal of ending HIV/AIDS in China by 2030 has faced several grand challenges including currently having a diagnostic rate of less than 85%, an estimated annual cost burden of 6.3 billion RMB for antiretroviral therapy (ART) alone, and the lack of therapeutic cure and preventive vaccine and so on. To address these challenges, Chinese scientists initiated the programme of Grand Challenges on HIV/AIDS in China (GCC) in 2017. The inauguration symposium was held from 30 November to 1 December 2017 in Hong Kong - Asia's World City - to commemorate the 10th anniversary of AIDS Institute at The University of Hong Kong and Comprehensive AIDS Research Center at Tsinghua University. The mission of the GCC is to advance HIV/AIDS prevention, prioritize research on therapeutic cure and vaccine, disseminate new scientific findings, and foster broader collaborations. Following the inaugural event, subsequent symposia were held at Fudan University in 2018, Sun Yat-Sen University in 2019, Tsinghua University in 2023, and Dali University in 2024. This review reports the scientific presentations and progresses made by the GCC scientists, highlighting efforts to combat HIV/AIDS in China.

Keywords: AIDS; China; HIV-1; cure; vaccine.

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Conflict of interest statement

No potential conflict of interest was reported by the author(s).

References

1. Lu L, Jia M, Ma Y, et al. . The changing face of HIV in China. Nature. 2008 Oct 2;455(7213):609–611. doi:10.1038/455609a - DOI - PubMed
1. Jia M, Luo H, Ma Y, et al. . The HIV epidemic in Yunnan Province, China, 1989-2007. J Acquir Immune Defic Syndr. 2010 Feb;53(Suppl 1):S34–S40. doi:10.1097/QAI.0b013e3181c7d6ff - DOI - PubMed
1. Zhang L, Chen Z, Cao Y, et al. . Molecular characterization of human immunodeficiency virus type 1 and hepatitis C virus in paid blood donors and injection drug users in china. J Virol. 2004 Dec;78(24):13591–9. doi:10.1128/JVI.78.24.13591-13599.2004 - DOI - PMC - PubMed
1. Zhang Y, Lu L, Ba L, et al. . Dominance of HIV-1 subtype CRF01_AE in sexually acquired cases leads to a new epidemic in Yunnan province of China. PLoS Med. 2006 Nov;3(11):e443. doi:10.1371/journal.pmed.0030443 - DOI - PMC - PubMed
1. Su B, Liu L, Wang F, et al. . HIV-1 subtype B’ dictates the AIDS epidemic among paid blood donors in the Henan and Hubei provinces of China. AIDS. 2003 Nov 21;17(17):2515–2520. doi:10.1097/00002030-200311210-00015 - DOI - PubMed

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[1] Lu L, Jia M, Ma Y, et al. . The changing face of HIV in China. Nature. 2008 Oct 2;455(7213):609–611. doi:10.1038/455609a - DOI - PubMed

[2] Lu L, Jia M, Ma Y, et al. . The changing face of HIV in China. Nature. 2008 Oct 2;455(7213):609–611. doi:10.1038/455609a - DOI - PubMed

[3] Jia M, Luo H, Ma Y, et al. . The HIV epidemic in Yunnan Province, China, 1989-2007. J Acquir Immune Defic Syndr. 2010 Feb;53(Suppl 1):S34–S40. doi:10.1097/QAI.0b013e3181c7d6ff - DOI - PubMed

[4] Jia M, Luo H, Ma Y, et al. . The HIV epidemic in Yunnan Province, China, 1989-2007. J Acquir Immune Defic Syndr. 2010 Feb;53(Suppl 1):S34–S40. doi:10.1097/QAI.0b013e3181c7d6ff - DOI - PubMed

[5] Zhang L, Chen Z, Cao Y, et al. . Molecular characterization of human immunodeficiency virus type 1 and hepatitis C virus in paid blood donors and injection drug users in china. J Virol. 2004 Dec;78(24):13591–9. doi:10.1128/JVI.78.24.13591-13599.2004 - DOI - PMC - PubMed

[6] Zhang L, Chen Z, Cao Y, et al. . Molecular characterization of human immunodeficiency virus type 1 and hepatitis C virus in paid blood donors and injection drug users in china. J Virol. 2004 Dec;78(24):13591–9. doi:10.1128/JVI.78.24.13591-13599.2004 - DOI - PMC - PubMed

[7] Zhang Y, Lu L, Ba L, et al. . Dominance of HIV-1 subtype CRF01_AE in sexually acquired cases leads to a new epidemic in Yunnan province of China. PLoS Med. 2006 Nov;3(11):e443. doi:10.1371/journal.pmed.0030443 - DOI - PMC - PubMed

[8] Zhang Y, Lu L, Ba L, et al. . Dominance of HIV-1 subtype CRF01_AE in sexually acquired cases leads to a new epidemic in Yunnan province of China. PLoS Med. 2006 Nov;3(11):e443. doi:10.1371/journal.pmed.0030443 - DOI - PMC - PubMed

[9] Su B, Liu L, Wang F, et al. . HIV-1 subtype B’ dictates the AIDS epidemic among paid blood donors in the Henan and Hubei provinces of China. AIDS. 2003 Nov 21;17(17):2515–2520. doi:10.1097/00002030-200311210-00015 - DOI - PubMed

[10] Su B, Liu L, Wang F, et al. . HIV-1 subtype B’ dictates the AIDS epidemic among paid blood donors in the Henan and Hubei provinces of China. AIDS. 2003 Nov 21;17(17):2515–2520. doi:10.1097/00002030-200311210-00015 - DOI - PubMed

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Grand Challenges on HIV/AIDS in China - The 5th Symposium, Yunnan 2024

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Grand Challenges on HIV/AIDS in China - The 5th Symposium, Yunnan 2024

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