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. 2025 Apr 9:27:e57782.
doi: 10.2196/57782.

Impact of Electronic Transition and Prefilled Templates on Drug Prescription Compliance: Retrospective Study

Aurélien Lambert  1   2 , Benoit Hombourger  1 , Julia Salleron  1 , Fadila Chergui  1 , Catherine Vallance  1 , Nadège Nicolas  1 , Marie Moussouni  1 , Lounisse Cherif  1 , Emile Chenot  1 , Céline Gavoille  1 , Vincent Massard  1
Affiliations

Impact of Electronic Transition and Prefilled Templates on Drug Prescription Compliance: Retrospective Study

Aurélien Lambert et al. J Med Internet Res. .

Abstract

Background: The transition from traditional handwritten prescriptions to electronic prescribing systems represents a significant advancement, with the potential to enhance treatment efficacy, patient safety, and professional communication.

Objective: This study aimed to examine the impact of this transition within a medical oncology service, assessing the compliance of electronic prescriptions with established good practice standards and exploring the associated risks.

Methods: In this retrospective analysis, we compared handwritten prescriptions from the pre-electronic era (January to May 2018) with electronic prescriptions (January to May 2021) following the implementation of the electronic prescribing system PandaLab Pro (PandaLab SAS). The inclusion criteria focused on outpatient oncology treatments, with a clear set of exclusion parameters to ensure a focused study scope. We defined good compliance as the written mention of the evaluated terms. The compliance rates were then compared using a chi-square test.

Results: Our findings, based on a sample size of 260 prescriptions (randomized among 30,526 archived prescriptions), indicate a substantial improvement in electronic prescriptions' compliance with prescribers and patient details, treatment accuracy, and overall adherence to regulatory standards. Notably, electronic formats achieved a remarkable 80.8% accuracy rate in compliance with safety criteria compared with 8.5% for handwritten prescriptions (P<.001). The use of prefilled prescriptions significantly increased compliance from a safety perspective (56% vs 96.2%; P<.001) compared with electronic prescriptions from scratch.

Conclusions: The analysis further underscores the advantages of prefilled electronic prescription templates, which significantly improved compliance rates compared with manually filled electronic and handwritten prescriptions. Furthermore, the study revealed a marked shift in prescribing behaviors, with electronic prescriptions tending to be more concise yet more numerous, suggesting an impact on medication management and patient adherence, which warrants further investigation. The study supports the transition to electronic prescribing systems in oncology, highlighting enhanced traceability, compliance with health authority standards, and patient safety. The implementation of prefilled templates supported by pharmacists has emerged as a pivotal factor in this improved process. While acknowledging certain limitations, such as the nonquantitative assessment of time savings and acceptability, this research advocates for the widespread adoption of electronic prescriptions and serves as a benchmark for future e-prescription initiatives in France.

Keywords: ambulatory care; drug prescription; electronic prescription; handwriting; medical oncology.

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Conflict of interest statement

Conflicts of Interest: None declared.

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