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. 2025 May 1;36(5):751-754.
doi: 10.1681/ASN.0000000696. Epub 2025 Apr 9.

Tubular Cell Polyploidy and AKI-to-CKD Transition

Elena Lazzeri  1 , Paola Romagnani  1   2
Affiliations

Tubular Cell Polyploidy and AKI-to-CKD Transition

Elena Lazzeri et al. J Am Soc Nephrol. .
No abstract available

Keywords: AKI; CKD.

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Conflict of interest statement

Disclosure forms, as provided by each author, are available with the online version of the article at http://links.lww.com/JSN/F121.

References

    1. Romagnani P Agarwal R Chan JCN, et al. . Chronic kidney disease. Nat Rev Dis Primers. 2025;11(1):8. doi:10.1038/s41572-024-00589-9 - DOI - PubMed
    1. De Chiara L, Lazzeri E, Romagnani P. Polyploid tubular cells: a shortcut to stress adaptation. Kidney Int. 2024;105(4):709–716. doi:10.1016/j.kint.2023.10.036 - DOI - PubMed
    1. De Chiara L Conte C Semeraro R, et al. . Tubular cell polyploidy protects from lethal acute kidney injury but promotes consequent chronic kidney disease. Nat Commun. 2022;13(1):5805. doi:10.1038/s41467-022-33110-5 - DOI - PMC - PubMed
    1. Lazzeri E Angelotti ML Peired A, et al. . Endocycle-related tubular cell hypertrophy and progenitor proliferation recover renal function after acute kidney injury. Nat Commun. 2018;9(1):1344. doi:10.1038/s41467-018-03753-4 - DOI - PMC - PubMed
    1. Airik M Phua YL Huynh AB, et al. . Persistent DNA damage underlies tubular cell polyploidization and progression to chronic kidney disease in kidneys deficient in the DNA repair protein FAN1. Kidney Int. 2022;102(5):1042–1056. doi:10.1016/j.kint.2022.07.003 - DOI - PMC - PubMed

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