Association of Clonal Hematopoiesis of Indeterminate Potential with Cardiovascular Events in Patients with CKD

Yang Pan¹, Caitlyn Vlasschaert², Varun Rao¹, Elvis A Akwo³, James E Hixson⁴, Md Mesbah Uddin⁵, Zhi Yu^{5

6}, Do-Kyun Kim⁴, Alexander Bick⁷, Bryan Kestenbaum⁸, Michael Chong^{9

10}, Guillaume Paré^{9

10}, Michael Rauh¹¹, Adeera Levin¹², James P Lash¹, Manjula Kurella Tamura¹³, Debbie L Cohen¹⁴, Jiang He¹⁵, Lee Hamm¹⁵, Rajat Deo¹⁶, Zeenat Bhat¹⁷, Panduranga Rao¹⁷, Dawei Xie¹⁸, Pradeep Natarajan^{5

6}, Tanika N Kelly¹, Cassianne Robinson-Cohen^{3

19}, Matthew B Lanktree^{10

20

21}; Canadian Study of Prediction of Death, Dialysis and Interim Cardiovascular Events (CanPREDDICT) and Chronic Renal Insufficiency Cohort (CRIC) Study Investigators

Collaborators, Affiliations

Collaborators

Canadian Study of Prediction of Death, Dialysis and Interim Cardiovascular Events (CanPREDDICT) and Chronic Renal Insufficiency Cohort (CRIC) Study Investigators:
Mohsen Agharazii, Joanne Blouin, France Samson, Ayub Akbarii, Judy Cheesman, Jennilea Courtney, Sabrina Hamer, Paul Barré, Jeffrey Golden, Brendan Barrett, Elizabeth Langille, Sandra Adams, Janet Morgan, Catherine Clase, Cathy Moreau, Susan Cooper, Brian Forzley, Susan Caron, Shauna Granger, Serge Cournoyer, Lorraine Menard, Michèle Roy, Hélène Skidmore, Dolores Beaudry, Janis Dionne, Josephine Chow, Valla Sahraei, Sandra Donnelly, Niki Dacouris, Rosa Marticorena, Brenda Hemmelgarn, Sharon Gulewich, Troy Hamilton, Paul Keown, Nadia Zalunardo, Daniel Rogers, Reena Tut, Matthew Paquette, Adeera Levin, Nancy Ferguson, Mila Tang, Kathleen Carlson, Lina Sioson, Charmaine Lok, Michelle Cross, François Madore, Manon Maltais, Louise Moist, Kerri Gallo, Sarah Langford, Leah Slamen, Norman Muirhead, Mary Jeanne Edgar, Taylor Gray, Cameron Edgar, Karen Groeneweg, Eileen McKinnon, Erin McRae, Bharat Nathoo, Kimmy Lau, Malvinder Parmar, Sylvie Gelinas, Martine Leblanc, Lucie Lépine, Claudio Rigatto, Dolores Friesen, Marla Penner, Steven Soroka, Susan Fleet, Jeanette Squires, Siva Thanamayooran, Michael Binder, Christine Hines, Brenda McNeil, Sheldon Tobe, Mary Chessman, Nancy Perkins, Martha Agelopoulos, Stacey Knox, Marcello Tonelli, Susan Szigety, Dawn Opgenorth, Karen Yeates, Karen Mahoney, Amanda H Anderson, Lawrence J Appel, Jing Chen, Laura M Dember, Alan S Go, Mahboob Rahman, Vallabh O Shah, Mark L Unruh

Affiliations

¹ Division of Nephrology, Department of Medicine, College of Medicine, University of Illinois Chicago, Chicago, Illinois.
² Department of Medicine, Queen's University, Kingston, Ontario, Canada.
³ Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
⁴ Department of Epidemiology, Human Genetics and Environmental Sciences, University of Texas Health Science Center at Houston School of Public Health, Houston, Texas.
⁵ Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT, Cambridge, Massachusetts.
⁶ Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts.
⁷ Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
⁸ Kidney Research Institute and Division of Nephrology, Department of Medicine, University of Washington, Seattle, Washington.
⁹ Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.
¹⁰ Population Health Research Institute, Hamilton, Ontario, Canada.
¹¹ Department of Pathology and Molecular Medicine, Queen's University, Kingston, Ontario, Canada.
¹² Division of Nephrology, The University of British Columbia, Vancouver, British Columbia, Canada.
¹³ Division of Nephrology, Stanford University School of Medicine, Palo Alto, California.
¹⁴ Renal-Electrolyte and Hypertension Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
¹⁵ Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana.
¹⁶ Division of Cardiovascular Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
¹⁷ Division of Nephrology, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, Michigan.
¹⁸ Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
¹⁹ Division of Hypertension, Vanderbilt Center for Kidney Disease, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
²⁰ Department of Medicine and Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada.
²¹ Division of Nephrology, St. Joseph's Healthcare Hamilton, Hamilton, Ontario, Canada.

PMID: 40202812
DOI: 10.1681/ASN.0000000671

Association of Clonal Hematopoiesis of Indeterminate Potential with Cardiovascular Events in Patients with CKD

Yang Pan et al. J Am Soc Nephrol. 2025.

. 2025 Apr 9;36(9):1775-1785.

doi: 10.1681/ASN.0000000671.

Authors

Collaborators

Canadian Study of Prediction of Death, Dialysis and Interim Cardiovascular Events (CanPREDDICT) and Chronic Renal Insufficiency Cohort (CRIC) Study Investigators:
Mohsen Agharazii, Joanne Blouin, France Samson, Ayub Akbarii, Judy Cheesman, Jennilea Courtney, Sabrina Hamer, Paul Barré, Jeffrey Golden, Brendan Barrett, Elizabeth Langille, Sandra Adams, Janet Morgan, Catherine Clase, Cathy Moreau, Susan Cooper, Brian Forzley, Susan Caron, Shauna Granger, Serge Cournoyer, Lorraine Menard, Michèle Roy, Hélène Skidmore, Dolores Beaudry, Janis Dionne, Josephine Chow, Valla Sahraei, Sandra Donnelly, Niki Dacouris, Rosa Marticorena, Brenda Hemmelgarn, Sharon Gulewich, Troy Hamilton, Paul Keown, Nadia Zalunardo, Daniel Rogers, Reena Tut, Matthew Paquette, Adeera Levin, Nancy Ferguson, Mila Tang, Kathleen Carlson, Lina Sioson, Charmaine Lok, Michelle Cross, François Madore, Manon Maltais, Louise Moist, Kerri Gallo, Sarah Langford, Leah Slamen, Norman Muirhead, Mary Jeanne Edgar, Taylor Gray, Cameron Edgar, Karen Groeneweg, Eileen McKinnon, Erin McRae, Bharat Nathoo, Kimmy Lau, Malvinder Parmar, Sylvie Gelinas, Martine Leblanc, Lucie Lépine, Claudio Rigatto, Dolores Friesen, Marla Penner, Steven Soroka, Susan Fleet, Jeanette Squires, Siva Thanamayooran, Michael Binder, Christine Hines, Brenda McNeil, Sheldon Tobe, Mary Chessman, Nancy Perkins, Martha Agelopoulos, Stacey Knox, Marcello Tonelli, Susan Szigety, Dawn Opgenorth, Karen Yeates, Karen Mahoney, Amanda H Anderson, Lawrence J Appel, Jing Chen, Laura M Dember, Alan S Go, Mahboob Rahman, Vallabh O Shah, Mark L Unruh

Affiliations

¹ Division of Nephrology, Department of Medicine, College of Medicine, University of Illinois Chicago, Chicago, Illinois.
² Department of Medicine, Queen's University, Kingston, Ontario, Canada.
³ Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
⁴ Department of Epidemiology, Human Genetics and Environmental Sciences, University of Texas Health Science Center at Houston School of Public Health, Houston, Texas.
⁵ Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT, Cambridge, Massachusetts.
⁶ Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts.
⁷ Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
⁸ Kidney Research Institute and Division of Nephrology, Department of Medicine, University of Washington, Seattle, Washington.
⁹ Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.
¹⁰ Population Health Research Institute, Hamilton, Ontario, Canada.
¹¹ Department of Pathology and Molecular Medicine, Queen's University, Kingston, Ontario, Canada.
¹² Division of Nephrology, The University of British Columbia, Vancouver, British Columbia, Canada.
¹³ Division of Nephrology, Stanford University School of Medicine, Palo Alto, California.
¹⁴ Renal-Electrolyte and Hypertension Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
¹⁵ Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana.
¹⁶ Division of Cardiovascular Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
¹⁷ Division of Nephrology, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, Michigan.
¹⁸ Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
¹⁹ Division of Hypertension, Vanderbilt Center for Kidney Disease, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
²⁰ Department of Medicine and Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada.
²¹ Division of Nephrology, St. Joseph's Healthcare Hamilton, Hamilton, Ontario, Canada.

PMID: 40202812
DOI: 10.1681/ASN.0000000671

No abstract available

Keywords: biomarkers; cardiovascular disease; cardiovascular events; chronic inflammation; clinical epidemiology; epidemiology and outcomes; human genetics; risk factors.

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References

1. Jankowski J, Floege J, Fliser D, Böhm M, Marx N. Cardiovascular disease in chronic kidney disease: pathophysiological insights and therapeutic options. Circulation. 2021;143(11):1157–1172. doi: 10.1161/CIRCULATIONAHA.120.050686 - DOI
1. Matsushita K, van der Velde M, Astor BC, et al.; Chronic Kidney Disease Prognosis Consortium. Association of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality in general population cohorts: a collaborative meta-analysis. Lancet. 2010;375(9731):2073–2081. doi: 10.1016/S0140-6736(10)60674-5 - DOI
1. Weiner DE, Tighiouart H, Amin MG, et al. Chronic kidney disease as a risk factor for cardiovascular disease and all-cause mortality: a pooled analysis of community-based studies. J Am Soc Nephrol. 2004;15(5):1307–1315. doi: 10.1097/01.ASN.0000123691.46138.e2 - DOI
1. Go AS, Chertow GM, Fan D, McCulloch CE, Hsu C. Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. New Engl J Med. 2004;351(13):1296–1305. doi: 10.1056/NEJMoa041031 - DOI
1. Matsushita K, Ballew SH, Wang AYM, Kalyesubula R, Schaeffner E, Agarwal R. Epidemiology and risk of cardiovascular disease in populations with chronic kidney disease. Nat Rev Nephrol. 2022;18(11):696–707. doi: 10.1038/s41581-022-00616-6 - DOI

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Association of Clonal Hematopoiesis of Indeterminate Potential with Cardiovascular Events in Patients with CKD

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Association of Clonal Hematopoiesis of Indeterminate Potential with Cardiovascular Events in Patients with CKD

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