Pharmacodynamic biomarkers responsive to mutant huntingtin lowering in a Huntington's disease mouse model

Deanna M Marchionini¹, Stef De Lombaerde², Joëlle van Rijswijk³, Franziska Zajicek⁴, Liesbeth Everix⁴, Alan Miranda⁴, Mari J Aaltonen⁵, Carleen M Kluger⁵, Thomas Wild⁵, Aglaia Kakoulidou⁵, Jannis Gundelach⁵, Tim Fieblinger⁵, Joachim Fentz⁵, Jim Rosinski⁶, John Obenauer⁷, Jonathan R Greene⁷, Longbin Liu⁶, Ignacio Munoz-Sanjuan⁶, Marleen Verhoye³, Jeroen Verhaeghe³, Jonathan Bard⁶, Steven Staelens³, Daniele Bertoglio⁸

Affiliations

¹ CHDI Management, Inc., The Company That Manages the Scientific Activities of CHDI Foundation, Inc., 350 7(th) Ave, Suite 200, New York, NY, 10001, USA. Electronic address: Deanna.Marchionini@CHDIFoundation.org.
² Molecular Imaging Center Antwerp (MICA), University of Antwerp, Campus Drie Eiken, Room D.UC.059, Universiteitsplein 1, B-2610 Wilrijk, Belgium.
³ Bio-Imaging Lab, University of Antwerp, Campus Drie Eiken, Building UC, Room 111, Universiteitsplein 1, B-2610 Wilrijk, Belgium; μNeuro Centre of Excellence, University of Antwerp, Campus Drie Eiken, Building N, D.N. 110, Universiteitsplein 1, B-2610 Wilrijk, Belgium.
⁴ Molecular Imaging Center Antwerp (MICA), University of Antwerp, Campus Drie Eiken, Room D.UC.059, Universiteitsplein 1, B-2610 Wilrijk, Belgium; μNeuro Centre of Excellence, University of Antwerp, Campus Drie Eiken, Building N, D.N. 110, Universiteitsplein 1, B-2610 Wilrijk, Belgium.
⁵ Evotec International GmbH, Anna-Sigmund-Str. 5, 82061, Neuried, Germany.
⁶ CHDI Management, Inc., The Company That Manages the Scientific Activities of CHDI Foundation, Inc., 350 7(th) Ave, Suite 200, New York, NY, 10001, USA.
⁷ Rancho Biosciences, 16955 Via Del Campo, Suite 200, San Diego, CA, 92127, USA.
⁸ Molecular Imaging Center Antwerp (MICA), University of Antwerp, Campus Drie Eiken, Room D.UC.059, Universiteitsplein 1, B-2610 Wilrijk, Belgium; Bio-Imaging Lab, University of Antwerp, Campus Drie Eiken, Building UC, Room 111, Universiteitsplein 1, B-2610 Wilrijk, Belgium; μNeuro Centre of Excellence, University of Antwerp, Campus Drie Eiken, Building N, D.N. 110, Universiteitsplein 1, B-2610 Wilrijk, Belgium.

PMID: 40204170
DOI: 10.1016/j.nbd.2025.106906

Free article

Pharmacodynamic biomarkers responsive to mutant huntingtin lowering in a Huntington's disease mouse model

Deanna M Marchionini et al. Neurobiol Dis. 2025.

Free article

. 2025 Jun 1:209:106906.

doi: 10.1016/j.nbd.2025.106906. Epub 2025 Apr 9.

Authors

Affiliations

¹ CHDI Management, Inc., The Company That Manages the Scientific Activities of CHDI Foundation, Inc., 350 7(th) Ave, Suite 200, New York, NY, 10001, USA. Electronic address: Deanna.Marchionini@CHDIFoundation.org.
² Molecular Imaging Center Antwerp (MICA), University of Antwerp, Campus Drie Eiken, Room D.UC.059, Universiteitsplein 1, B-2610 Wilrijk, Belgium.
³ Bio-Imaging Lab, University of Antwerp, Campus Drie Eiken, Building UC, Room 111, Universiteitsplein 1, B-2610 Wilrijk, Belgium; μNeuro Centre of Excellence, University of Antwerp, Campus Drie Eiken, Building N, D.N. 110, Universiteitsplein 1, B-2610 Wilrijk, Belgium.
⁴ Molecular Imaging Center Antwerp (MICA), University of Antwerp, Campus Drie Eiken, Room D.UC.059, Universiteitsplein 1, B-2610 Wilrijk, Belgium; μNeuro Centre of Excellence, University of Antwerp, Campus Drie Eiken, Building N, D.N. 110, Universiteitsplein 1, B-2610 Wilrijk, Belgium.
⁵ Evotec International GmbH, Anna-Sigmund-Str. 5, 82061, Neuried, Germany.
⁶ CHDI Management, Inc., The Company That Manages the Scientific Activities of CHDI Foundation, Inc., 350 7(th) Ave, Suite 200, New York, NY, 10001, USA.
⁷ Rancho Biosciences, 16955 Via Del Campo, Suite 200, San Diego, CA, 92127, USA.
⁸ Molecular Imaging Center Antwerp (MICA), University of Antwerp, Campus Drie Eiken, Room D.UC.059, Universiteitsplein 1, B-2610 Wilrijk, Belgium; Bio-Imaging Lab, University of Antwerp, Campus Drie Eiken, Building UC, Room 111, Universiteitsplein 1, B-2610 Wilrijk, Belgium; μNeuro Centre of Excellence, University of Antwerp, Campus Drie Eiken, Building N, D.N. 110, Universiteitsplein 1, B-2610 Wilrijk, Belgium.

PMID: 40204170
DOI: 10.1016/j.nbd.2025.106906

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Conflict of interest statement

Declaration of competing interest CHDI Foundation is a nonprofit biomedical research organization exclusively dedicated to collaboratively developing therapeutics that substantially improve the lives of those affected by Huntington's disease. CHDI Foundation conducts research in a number of different ways; for the purposes of this manuscript, all research was conceptualized, planned and directed by all authors and the University of Antwerp or at the contract research organizations Psychogenics, Evotec SE and Rancho Biosciences. No other potential conflicts of interest exist.

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Pharmacodynamic biomarkers responsive to mutant huntingtin lowering in a Huntington's disease mouse model

Affiliations

Pharmacodynamic biomarkers responsive to mutant huntingtin lowering in a Huntington's disease mouse model

Authors

Affiliations

Conflict of interest statement

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