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Review
. 2025 Sep;39(3):465-482.
doi: 10.1016/j.idc.2025.02.014. Epub 2025 Apr 9.

Diabetic Foot Infections

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Review

Diabetic Foot Infections

Laila M Castellino et al. Infect Dis Clin North Am. 2025 Sep.

Abstract

Diabetes is a growing public health concern, with diabetic foot infections (DFI) being one of the leading causes of lower extremity limb amputation in the United States. Accurate diagnosis of DFI requires a combination of clinical, laboratory, and radiologic tests to determine the extent and depth of infection, including the presence of osteomyelitis. Treatment often includes a combination of antibiotics and surgical debridement. Addressing comorbidities such as peripheral vascular disease, glycemic control, and offloading pressure from ulcers and bony prominences is paramount to achieving a successful outcome, and patients should ideally be managed by dedicated interdisciplinary teams.

Keywords: Diabetic foot infection; Offloading; Osteomyelitis; Peripheral vascular disease.

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Conflict of interest statement

Disclosure All authors report no conflicts of interest related to this work.

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