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Randomized Controlled Trial
. 2025 Aug;29(8):2483-2494.
doi: 10.1007/s10461-025-04709-8. Epub 2025 Apr 10.

The Association Between Use of Adherence Support Interventions and Adherence to HIV Preexposure Prophylaxis Among Young South African and Zimbabwean Women in HPTN 082

Abubaker Ibrahim Elbur  1 , D Donnell  2 , S Hosek  3   4 , B Dye  5 , J Velloza  6 , S Delany-Moretlwe  3 , C Celum  7
Affiliations
Randomized Controlled Trial

The Association Between Use of Adherence Support Interventions and Adherence to HIV Preexposure Prophylaxis Among Young South African and Zimbabwean Women in HPTN 082

Abubaker Ibrahim Elbur et al. AIDS Behav. 2025 Aug.

Erratum in

Abstract

We assessed the association between PrEP adherence support interventions and intracellular tenofovir-diphosphate (TFV-DP) levels, a biomarker for PrEP adherence, using data from 368 South African and Zimbabwean adolescent girls and young women enrolled in the HIV Prevention Trials Network 082 trial from 2016 to 2018. Group-based trajectory modeling identified trajectories of TFV-DP levels and adherence support interventions, including weekly two-way SMS and optional monthly adherence clubs. Two trajectories of TFV-DP levels were identified: a consistently low trajectory (N = 248, 67.4%, with consistent TFV-DP levels of 100 fmol/punch) and a high-decreasing trajectory (N = 120, 32.6%, with TFV-DP levels decreasing from approximately 900 to 500 fmol/punch). Two trajectories were also observed for adherence club attendance: consistently moderate (N = 249, 67.7%, attended approximately two out of three clubs in a three-month period) and low-increasing (N = 119, 32.3%). Similarly, SMS response patterns included a consistently high engagement group (N = 222, 66.1%), who responded to approximately 90% of messages, and a consistently low engagement group (N = 114, 33.9%). Women with consistently high SMS responses had higher odds of being in the high-decreasing TFV-DP levels trajectory group (Adjusted Odds Ratio [AOR]: 6.6; 95% CI 2.8-15.5; p < 0.001), while those with a consistently moderate adherence club attendance trajectory had an AOR of 1.3 (95% CI 0.5-3.3, p = 0.620) for being in the same group. Use of PrEP was aligned with the higher response trajectories of SMS responses but not with attendance to adherence support clubs.

Keywords: Adherence support clubs; Adolescent girls and young women; HIV; Pre-exposure prophylaxis; Sub-Saharan Africa; Two-way SMS.

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Conflict of interest statement

Declarations. Competing Interests: No relevant financial or non-financial competing interests to report.

Figures

Fig. 1
Fig. 1
Trajectories of TFV-DP levels in DBS
Fig. 2
Fig. 2
Trajectories of voluntary attendance in monthly adherence clubs
Fig. 3
Fig. 3
Trajectories of responses to 2-way SMS
See this image and copyright information in PMC

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