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. 2025 Aug;29(8):2461-2482.
doi: 10.1007/s10461-025-04708-9. Epub 2025 Apr 10.

Perspectives on COVID-19 Vaccination Among Unvaccinated and Under-Vaccinated African American/Black and Latine Frontline Essential Workers: A Qualitative Exploration

Affiliations

Perspectives on COVID-19 Vaccination Among Unvaccinated and Under-Vaccinated African American/Black and Latine Frontline Essential Workers: A Qualitative Exploration

Marya Gwadz et al. AIDS Behav. 2025 Aug.

Abstract

Racial/ethnic disparities in COVID-19 morbidity and mortality are serious in the United States, particularly among African American/Black and Latine (AABL) populations. Staying up-to-date on COVID-19 vaccination is essential for mitigating risk, but AABL vaccination rates are low. The present qualitative study explores perspectives on COVID-19 among AABL persons at high-risk for exposure to the SARS-CoV- 2 virus: frontline essential workers engaged in public-facing professions (e.g., retail). From a larger study of AABL frontline essential workers not up-to-date on COVID-19 vaccination, N = 50 participants were purposively sampled for maximum variability. Participants engaged in semi-structured qualitative interviews in English or Spanish that were audio-recorded, professionally transcribed, and translated into English as needed. Data were analyzed using a directed content analysis approach that was both inductive and theory-driven. Participants were 37 years old, on average, and most (65%) were men. Approximately half (56%) were Latine/Hispanic and 44% were African American/Black. Occupations included food preparation (40%), retail (28%), construction (12%), in-home health care (8%), and building maintenance and personal services (12%). Approximately a third (38%) had received ≥ 1 COVID-19 vaccine dose. We found COVID-19 vaccination perspectives were grounded in a larger context of medical and institutional distrust and past/ongoing systemic racism. In this context, results were organized into the following themes: general perspectives on COVID-19; barriers/facilitators related to race/ethnicity, social class, and community; specific aspects of the COVID-19 vaccine as barriers; mandates, incentives, and pressures to be vaccinated; and mixed effects of public health initiatives. Overall, participants were knowledgeable about COVID-19. Social norms reduced vaccine intentions but altruism and community/family concern could motivate it. Aspects of the public health response (e.g., advertisement campaigns targeting AABL populations) increased distrust and reduced vaccination willingness. However, at least some ambivalence about vaccination was common (participants would consider it). Yet there was a large gap between considering and receiving vaccination. Thus, barriers to COVID-19 vaccination for AABL frontline essential workers operate at multiple levels of influence, but are addressable. The present study yields recommendations to improve vaccination, including increasing the trustworthiness of systems and institutions, reducing systemic/structural barriers, harnessing social forces, and engaging AABL communities in program planning.

Keywords: African American/Black and Latine frontline essential workers; COVID-19 vaccination; Medical distrust; Qualitative; RADX-up; Racial/ethnic disparities; Vaccine hesitancy.

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Conflict of interest statement

Declarations. Competing Interests: The authors declare that they have no competing interests. Ethical Approval: The study was conducted in accordance with the Declaration of Helsinki. Procedures were approved by the Institutional Review Board at New York University (FWA00006386). Participants gave informed consent for study activities. Consent for Publication: Not applicable.

Figures

Fig. 1
Fig. 1
Overview of themes found in the present study
Fig. 2
Fig. 2
Recommendations for improving COVID-19 vaccine uptake based on study findings

References

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