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. 1985 Feb;13(1):41-53.
doi: 10.1007/BF01073655.

Pharmacokinetics of theobromine and its metabolites in rabbits

G L Traina, M Bonati

Pharmacokinetics of theobromine and its metabolites in rabbits

G L Traina et al. J Pharmacokinet Biopharm. 1985 Feb.

Abstract

The pharmacokinetics of theobromine (3, 7-DMX) and its metabolites was investigated in detail in four male rabbits after bolus intravenous injection (4 mg/kg) of the compound. Apparent first-order rate constants for the metabolic processes involved in the formation of 3,7-DMX metabolites and their excretion in urine were calculated. Theobromine, 7-methylxanthine (7-MX) and 3-methylxanthine (3-MX) were measured in blood and urine, and the other metabolites were determined only in urine. An appropriate model of 14 compartments is formulated to describe the disposition of 3,7-DMX and its metabolites.

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