Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2025 Mar 18:52:100672.
doi: 10.1016/j.jbo.2025.100672. eCollection 2025 Jun.

Pain in patients with multiple inherited osteochondromas: Incidence and potential prognostic factors. A retrospective cohort study

Morena Tremosini  1 , Mattia Morri  1 , Cristiana Forni  1 , Elena Pedrini  2 , Marina Mordenti  2 , Maria Gnoli  2 , Alessia Di Cecco  1 , Alice Moroni  2 , Luca Sangiorgi  2
Affiliations

Pain in patients with multiple inherited osteochondromas: Incidence and potential prognostic factors. A retrospective cohort study

Morena Tremosini et al. J Bone Oncol. .

Abstract

Purpose: the purpose of this study was to describe the baseline characteristics, presenting phenotype and treatment interventions for patients diagnosed with multiple osteochondromas who presented with severe pain symptoms.

Methods: a retrospective single-centre cohort study was conducted at a Rare Skeletal Disorders Department. Pain symptomatology was measured at the first visit, pain level was reported, varying from 0, absence of pain to 10, maximum pain. Baseline characteristics, pathology phenotype using IOR classification and treatments performed/ongoing as medical, surgical and conservative therapies were collected.

Results: a total of 152 patients were enrolled, with a median pain score of 0 and the 25th and 75th percentiles of 0 and 4, respectively. A percentage of 25.7 % (95 % CI of 19.3-33.3) presented at the first visit with moderate/severe pain. Multiple logistic regression confirmed that age was the only factor to be significantly associated with moderate/severe pain and IOR classification was not able to provide a description of the pathology that was associated with a major pain score.

Conclusion: from the early stages of multiple osteochondromas diagnosis, pain symptoms must be carefully assessed. An increase in age is associated with a worsening of pain; IOR classification of the multiple osteochondromas phenotype does not currently allow an association between the various classes and pain. A re-evaluation of the classification in this light could be an important new element for clinical practice.

Keywords: Multiple osteochondromas; Pain; Prognostic factors; Rare bone disease.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

References

    1. Bovée J.V.M.G. Multiple osteochondromas. Orphanet J. Rare Diseases. 2008;3:3. doi: 10.1186/1750-1172-3-3. - DOI - PMC - PubMed
    1. Jennes I., Pedrini E., Zuntini M., Mordenti M., Balkassmi S., Asteggiano C.G., Wuyts W. Multiple osteochondromas: mutation update and description of the multiple osteochondromas mutation database (MOdb) Hum. Mutat. 2009;30(12):1620–1627. doi: 10.1002/humu.21123. - DOI - PubMed
    1. Ryckx A., Somers J.F.A., Allaert L. Hereditary multiple exostosis. Acta Orthop. Belg. 2013;79(6):597–607. - PubMed
    1. Schmale G.A., Conrad E.U., Raskind W.H. The natural history of hereditary multiple exostoses. The J. Bone and Joint Surgery. American. 1994;76(7):986–992. doi: 10.2106/00004623-199407000-00005. - DOI - PubMed
    1. Portale delle Malattie Rare. (n.d.). Retrieved July 25, 2024, from https://www.malattierare.gov.it/malattie/dettaglio/3603?sezioneCorrente=....

LinkOut - more resources