Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2025 Mar 17:10:101035.
doi: 10.1016/j.crfs.2025.101035. eCollection 2025.

Defatted chia (Salvia hispanica L.) flour peptides: Exploring nutritional profiles, techno-functional and bio-functional properties, and future directions

Affiliations
Review

Defatted chia (Salvia hispanica L.) flour peptides: Exploring nutritional profiles, techno-functional and bio-functional properties, and future directions

Etty Syarmila Ibrahim Khushairay et al. Curr Res Food Sci. .

Abstract

Chia (Salvia hispanica L.) is a summer-blooming herb from the mint family, known for its rich nutritional profile, including high-quality protein, fibre, and a balanced ratio of omega-3 and omega-6 fatty acids. With the rising demand for chia oil, defatted chia flour (DCF), a by-product of oil extraction, has gained attention as a valuable ingredient. DCF is rich in essential macronutrients and amino acids, offering a sustainable alternative to traditional protein sources and supporting global food sustainability and waste reduction efforts. Recent studies have highlighted the techno-functional properties of DCF peptides, showing excellent solubility, water- and oil-absorption capacities, as well as emulsifying, foaming, and gelling abilities. These properties enhance their application in diverse food systems, making DCF an important ingredient in the development of nutritious, innovative, and appealing food products. Beyond their functional roles, chia-derived peptides also exhibit significant bioactive properties, such as antioxidants, antihypertensive, anti-inflammatory, neuroprotective, antidiabetic, antimicrobial, anti-aging, hypolipidemic, and hypoglycaemic effects. These properties make them beneficial for improving health and wellness. Integrating DCF peptides into food products provides a natural approach to managing chronic diseases, promoting longevity, and improving overall health. To fully realize the potential of DCF peptides, future research should focus on understanding their bioactivities at the molecular level and exploring how they interact with various physiological systems. Interdisciplinary collaboration among food science, biotechnology, pharmacology, and nutrition is essential, along with careful evaluation of safety and potential risks. Regulatory frameworks will be crucial for the broader use of DCF peptides in food and nutraceuticals. Additionally, advancements in peptide production, extraction, and purification technologies will be necessary for large-scale, sustainable applications. Focusing on these areas will maximize the benefits of chia peptides for human health, nutrition, and environmental sustainability.

Keywords: Bio-functional properties; Defatted chia flour; Future directions; Nutritional profiles; Peptides; Techno-functional attributes.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interests.

Figures

Image 1
Graphical abstract
Fig. 1
Fig. 1
Types of chia seeds. (Left) Black chia seeds; (Right) White chia seeds.
Fig. 2
Fig. 2
Nutritional compositions of dry chia seeds.
Fig. 3
Fig. 3
Overview of the essential techniques involved in the production of chia peptides.
Fig. 4
Fig. 4
Applications of chia seeds-derived ingredients in food product development.

References

    1. Absi Y., Revilla I., Vivar-Quintana A.M. Commercial hemp (Cannabis sativa Subsp. sativa) proteins and flours: nutritional and techno-functional properties. Appl. Sci. 2023;13 doi: 10.3390/app131810130. - DOI
    1. Agarwal A., Rizwana, Tripathi A.D., Kumar T., Sharma K.P., Patel S.K.S. Nutritional and functional new perspectives and potential health benefits of quinoa and chia seeds. Antioxidants. 2023;12:1413. doi: 10.3390/antiox12071413. - DOI - PMC - PubMed
    1. Aguilar-Toala J.E., Liceaga A.M. Identification of chia seed (Salvia hispanica L.) peptides with enzyme inhibition activity towards skin-aging enzymes. Amino Acids. 2020;52:1149–1159. doi: 10.1007/s00726-020-02879-4. - DOI - PubMed
    1. Aguilar-Toala J.E., Deering A.J., Liceaga A.M. New insights into the antimicrobial properties of hydrolysates and peptide fractions derived from chia seed (Salvia hispanica L.). Probiotics Antimicrob. Proteins. 2020;12:1571–1581. doi: 10.1007/s12602-020-09653-8. - DOI - PubMed
    1. Ahmed J., Mulla M., Al-Ruwaih N., Arfat Y.A. Effect of high-pressure treatment prior to enzymatic hydrolysis on rheological, thermal, and antioxidant properties of lentil protein isolate. Legume Sci. 2019;1:e10. doi: 10.1002/leg3.10. - DOI

LinkOut - more resources