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Editorial
. 2025 Apr 10:14:e106689.
doi: 10.7554/eLife.106689.

When cell teamwork turns toxic

Wadih E I Khoury  1 , Stephen Y Chan  1
Affiliations
Editorial

When cell teamwork turns toxic

Wadih E I Khoury et al. Elife. .

Abstract

In pulmonary hypertension, a combination of metabolic and mechanical dysfunction leads to irreversible vascular damage.

Keywords: adventitial fibroblasts; cell biology; human; medicine; pulmonary artery; pulmonary hypertension; vascular smooth muscle cells.

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Conflict of interest statement

WK No competing interests declared, SC Consultant for Merck, Janssen, and United Therapeutics; director, officer, and shareholder in Synhale Therapeutics; has held grants from Bayer and United Therapeutics; has filed patent applications regarding metabolism and next-generation therapeutics in pulmonary hypertension (US 10,925,869 B2; PCT/US2015/029286; PCT/US2018/062013; US 11,773,391 B2; PCT/IB2023/055431)

Figures

Figure 1.
Figure 1.. Progression from healthy pulmonary artery adventitial fibroblasts (PAAFs) and pulmonary artery smooth muscle cells (PASMCs) to pulmonary hypertension (PH) phenotype.
In healthy arteries (left), PASMCs are dynamic cells that regulate flow and pressure in the lung vasculature by contracting and dilating, while the fibroblasts on the vessel’s outer layer (PAAFs) protect PASMCs (green triangles). In pulmonary hypertension, PAAFs overproduce collagen and harmful proteins (red triangles) that cause PASMCs to become rigid. Imbalanced protein dynamics and mitochondrial dysfunction in both cell types further contribute to the diseased state (right). Created with BioRender.com.
See this image and copyright information in PMC

Comment on

  • doi: 10.7554/eLife.98558

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