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Review
. 2025 Jan-Dec:24:15330338251334447.
doi: 10.1177/15330338251334447. Epub 2025 Apr 10.

Zinc Finger Proteins in Colorectal Cancer: Insights into Molecular Mechanisms and Therapeutic Implications

Chongyuan Lan  1 , Ming Qiu  1 , Minglin Lin  1   2
Affiliations
Review

Zinc Finger Proteins in Colorectal Cancer: Insights into Molecular Mechanisms and Therapeutic Implications

Chongyuan Lan et al. Technol Cancer Res Treat. 2025 Jan-Dec.

Abstract

Colorectal cancer ranks as one of the most common malignancies globally, with mortality rates second only to lung cancer. Despite improvements in diagnostic and therapeutic approaches, long-term survival rates for colorectal cancer patients remain unsatisfactory. The onset and progression of this disease involve intricate molecular mechanisms, influenced by a range of biological factors. Zinc finger proteins play a critical role in these processes, impacting tumor development and patient prognosis. This review summarizes current research on zinc finger proteins in colorectal cancer, highlighting key findings and advancements in understanding their role in tumor biology.

Keywords: colorectal cancer; transcription factor; tumor biology; zinc finger protein.

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Conflict of interest statement

Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
Zinc Finger Proteins Play a Vital Role in Living Organisms. The Figure Illustrates the Structure of Zinc Finger Proteins and the Various Biological Functions: Transcriptional Regulation, DNA Repair, Post-Translational.
Figure 2.
Figure 2.
Zic2 Inhibits Axin2 Transcription, Resulting in β-Catenin Accumulation and Heightened Wnt Signaling, Which Drives Downstream Gene Transcription and CRC Cell Proliferation.
Figure 3.
Figure 3.
ZNF70 Activates the STAT3 Pathway to Promote IL-1β Secretion by Macrophages, Facilitating CRC Cell Proliferation.
See this image and copyright information in PMC

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