Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2025 Jan-Dec:24:15330338251334447.
doi: 10.1177/15330338251334447. Epub 2025 Apr 10.

Zinc Finger Proteins in Colorectal Cancer: Insights into Molecular Mechanisms and Therapeutic Implications

Chongyuan Lan  1 , Ming Qiu  1 , Minglin Lin  1   2
Affiliations
Review

Zinc Finger Proteins in Colorectal Cancer: Insights into Molecular Mechanisms and Therapeutic Implications

Chongyuan Lan et al. Technol Cancer Res Treat. 2025 Jan-Dec.

Abstract

Colorectal cancer ranks as one of the most common malignancies globally, with mortality rates second only to lung cancer. Despite improvements in diagnostic and therapeutic approaches, long-term survival rates for colorectal cancer patients remain unsatisfactory. The onset and progression of this disease involve intricate molecular mechanisms, influenced by a range of biological factors. Zinc finger proteins play a critical role in these processes, impacting tumor development and patient prognosis. This review summarizes current research on zinc finger proteins in colorectal cancer, highlighting key findings and advancements in understanding their role in tumor biology.

Keywords: colorectal cancer; transcription factor; tumor biology; zinc finger protein.

PubMed Disclaimer

Conflict of interest statement

Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
Zinc Finger Proteins Play a Vital Role in Living Organisms. The Figure Illustrates the Structure of Zinc Finger Proteins and the Various Biological Functions: Transcriptional Regulation, DNA Repair, Post-Translational.
Figure 2.
Figure 2.
Zic2 Inhibits Axin2 Transcription, Resulting in β-Catenin Accumulation and Heightened Wnt Signaling, Which Drives Downstream Gene Transcription and CRC Cell Proliferation.
Figure 3.
Figure 3.
ZNF70 Activates the STAT3 Pathway to Promote IL-1β Secretion by Macrophages, Facilitating CRC Cell Proliferation.
See this image and copyright information in PMC

References

    1. Rassy E, Parent P, Lefort F, Boussios S, Baciarello G, Pavlidis N. New rising entities in cancer of unknown primary: Is there a real therapeutic benefit? Crit Rev Oncol Hematol. 2020;147:102882. - PubMed
    1. Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209-249. - PubMed
    1. Osseis M, Nehmeh WA, Rassy N, et al. Surgery for T4 colorectal cancer in older patients: Determinants of outcomes. J Pers Med. 2022;12(9):1534. - PMC - PubMed
    1. Wang H, Li Z, Tao Y, et al. Characterization of endoplasmic reticulum stress unveils ZNF703 as a promising target for colorectal cancer immunotherapy. J Transl Med. 2023;21(1):713. - PMC - PubMed
    1. Qin C, Li A, Xiao Y, et al. Expression of ZNF281 in colorectal cancer correlates with response to radiotherapy and survival. Ann Med. 2023;55(2):2278619. - PMC - PubMed

Substances

LinkOut - more resources