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. 1985 Sep;55(3):840-2.
doi: 10.1128/JVI.55.3.840-842.1985.

Properties of monoclonal antibodies against glycoproteins of western equine encephalitis virus

K Yamamoto, K Hashimoto, J Chiba, B Simizu

Properties of monoclonal antibodies against glycoproteins of western equine encephalitis virus

K Yamamoto et al. J Virol. 1985 Sep.

Abstract

To analyze the biological activities of the alphavirus glycoproteins, eight different monoclonal antibodies against the two glycoproteins of western equine encephalitis virus were isolated. Five of the eight monoclonal antibodies were shown to be specific for E1 and three for E2 protein by an enzyme-linked immunosorbent assay and by radioimmunoprecipitation. Three of the five anti-E1 and all of the anti-E2 monoclonal antibodies inhibited hemagglutination by purified virions. One anti-E1 and two anti-E2 monoclonal antibodies possessed high virus-neutralizing activity.

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