Short- and long-term outcomes of endoscopic resection for gastric tube cancer: a Japanese multicenter prospective cohort study

Yosuke Tsuji¹, Haruhisa Suzuki², Kohei Takizawa³, Toshiaki Hirasawa⁴, Yoji Takeuchi⁵, Kenji Ishido⁶, Shu Hoteya⁷, Tomonori Yano⁸, Shinji Tanaka⁹, Yosuke Toya¹⁰, Masahiro Nakagawa¹¹, Takashi Toyonaga¹², Naohiro Yoshida¹³, Kingo Hirasawa¹⁴, Mitsuru Matsuda¹⁵, Hironori Yamamoto¹⁶, Mitsuhiro Fujishiro¹⁷, Yuji Naito¹⁸, Katsumi Yamamoto¹⁹, Nozomu Kobayashi²⁰, Yoshiro Kawahara²¹, Masaaki Hirano²², Taichi Shimazu²³, Hiroyuki Ono²⁴, Satoshi Tanabe²⁵, Hitoshi Kondo²⁶, Hiroyasu Iishi²⁷, Motoki Ninomiya²⁸, Ichiro Oda²⁹; J-WEB/EGC Group

Collaborators, Affiliations

Collaborators

J-WEB/EGC Group:
Satoru Hashimoto³⁰, Dai Hirasawa³¹, Tsuneo Oyama³², Ryuta Takenaka³³, Yoshinobu Yamamoto³⁴, Shigeto Koizumi³⁵, Shinichiro Hori³⁶, Masahiro Tajika³⁷, Takuto Hikichi³⁸, Kenshi Yao³⁹, Chizu Yokoi⁴⁰, Ken Ohnita⁴¹, Yasuhiro Hisanaga⁴², Tetsuya Sumiyoshi²⁶, Shinji Kitamura⁴³, Hisao Tanaka⁴⁴, Ryo Shimoda⁴⁵, Yumi Mashimo⁴⁶, Ryutaro Morizono⁴⁷, Kazutoshi Fukase⁴⁸

Affiliations

¹ Next-Generation Endoscopic Computer Vision, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan; Department of Gastroenterology, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan.
² Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine.
³ Division of Endoscopy, Shizuoka Cancer Center, Shizuoka, Japan; Department of Gastroenterology, Kanagawa Cancer Center, Kanagawa, Japan.
⁴ Department of Gastroenterology, Cancer Institute Hospital, Tokyo, Japan.
⁵ Department of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan; Department of Endoscopy and Endoscopic Surgery, Gunma University Hospital, Gunma, Japan.
⁶ Department of Gastroenterology, Kitasato University School of Medicine, Sagamihara, Japan.
⁷ Department of Gastroenterology, Toranomon Hospital, Tokyo, Japan.
⁸ Department of Gastroenterology and Endoscopy, National Cancer Center Hospital East, Kashiwa, Japan.
⁹ President, JA Onomichi General Hospital, Professor Emeritus, Hiroshima University, and Visiting Professor, Gastroenterology, Graduate School of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan.
¹⁰ Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Iwate Medical University, Yahaba, Japan.
¹¹ Department of Endoscopy, Hiroshima City Hiroshima Citizens Hospital, Hiroshima, Japan.
¹² Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
¹³ Department of Gastroenterology, Ishikawa Prefectural Central Hospital, Kanazawa, Japan.
¹⁴ Division of Endoscopy, Yokohama City University Medical Center, Yokohama, Japan.
¹⁵ Department of Gastroenterology, Toyama Prefectural Central Hospital, Toyama, Japan.
¹⁶ Department of Medicine, Division of Gastroenterology, Jichi Medical University, Tochigi, Japan.
¹⁷ Department of Gastroenterology, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan.
¹⁸ Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
¹⁹ Department of Gastroenterology, Japan Community Healthcare Organization Osaka Hospital, Osaka, Japan.
²⁰ Department of Gastroenterology, Tochigi Cancer Center, Utsunomiya, Japan; Endoscopy Division, National Cancer Center Hospital, Tokyo, Japan.
²¹ Department of Practical Gastrointestinal Endoscopy, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
²² Department of Internal Medicine, Keinan General Hospital, Niigata, Japan.
²³ Division of Behavioral Sciences, National Cancer Center Institute for Cancer Control, National Cancer Center, Tokyo, Japan.
²⁴ Division of Endoscopy, Shizuoka Cancer Center, Shizuoka, Japan.
²⁵ Department of Gastroenterology, Kitasato University School of Medicine, Sagamihara, Japan; Department of Gastroenterology, Ebina General Hospital, Ebina, Japan.
²⁶ Department of Gastroenterology, Tonan Hospital, Sapporo, Japan.
²⁷ Department of Gastroenterology, Itami City Hospital, Itami, Hyogo, Japan.
²⁸ Digestive Disease Center, Yuuai Medical Center, Okinawa, Japan.
²⁹ Endoscopy Division, National Cancer Center Hospital, Tokyo, Japan; Department of Internal Medicine, Kawasaki Rinko General Hospital, Kanagawa, Japan. Electronic address: ioda@ncc.go.jp.
³⁰ Division of Gastroenterology and Hepatology, Niigata University Medical and Dental Hospital, Niigata, Japan.
³¹ Department of Gastroenterology, Maztuzono 2nd Hospital, Morioka, Japan.
³² Department of Endoscopy, Saku Central Hospital Advanced Care Center, Nagano, Japan.
³³ Department of Gastroenterology, Tsuyama Chuo Hospital, Tsuyama, Japan.
³⁴ Department of Gastroenterological Oncology, Hyogo Cancer Center, Akashi, Japan.
³⁵ Department of Gastroenterology, Akita University Graduate School of Medicine and Koizumi Hospital, Akita, Japan.
³⁶ Department of Gastroenterology, National Hospital Organization Shikoku Cancer Center, Matuyama, Japan.
³⁷ Department of Endoscopy, Aichi Cancer Center Hospital, Nagoya, Japan.
³⁸ Department of Endoscopy, Fukushima Medical University Hospital, Fukushima, Japan.
³⁹ Department of Endoscopy, Fukuoka University Chikushi Hospital, Fukuoka, Japan.
⁴⁰ Department of Gastroenterology, National Center for Global Health and Medicine, Tokyo, Japan.
⁴¹ Department of Gastroenterology and Hepatology, Nagasaki University Hospital, Nagasaki, Japan.
⁴² Department of Gastroenterology, Ogaki Municipal Hospital, Ogaki, Japan.
⁴³ Department of Gastroenterology and Oncology, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.
⁴⁴ Chiyominomori General Medicine and Gastroenterology Clinic, Tottori, Japan.
⁴⁵ Department of Endoscopic Diagnostics and Therapeutics, Saga University Hospital, Saga, Japan.
⁴⁶ Department of Gastroenterology, Chofu Touzan Hospital, Tokyo, Japan.
⁴⁷ Department of Surgery, Kin-i-kyo Central Hospital, Sapporo, Japan.
⁴⁸ Department of Gastroenterology, Yamagata Prefectural Central Hospital, Yamagata, Japan.

PMID: 40210015
DOI: 10.1016/j.gie.2025.04.002

Short- and long-term outcomes of endoscopic resection for gastric tube cancer: a Japanese multicenter prospective cohort study

Yosuke Tsuji et al. Gastrointest Endosc. 2025.

. 2025 Apr 8:S0016-5107(25)01505-6.

doi: 10.1016/j.gie.2025.04.002. Online ahead of print.

Authors

Collaborators

J-WEB/EGC Group:
Satoru Hashimoto³⁰, Dai Hirasawa³¹, Tsuneo Oyama³², Ryuta Takenaka³³, Yoshinobu Yamamoto³⁴, Shigeto Koizumi³⁵, Shinichiro Hori³⁶, Masahiro Tajika³⁷, Takuto Hikichi³⁸, Kenshi Yao³⁹, Chizu Yokoi⁴⁰, Ken Ohnita⁴¹, Yasuhiro Hisanaga⁴², Tetsuya Sumiyoshi²⁶, Shinji Kitamura⁴³, Hisao Tanaka⁴⁴, Ryo Shimoda⁴⁵, Yumi Mashimo⁴⁶, Ryutaro Morizono⁴⁷, Kazutoshi Fukase⁴⁸

Affiliations

¹ Next-Generation Endoscopic Computer Vision, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan; Department of Gastroenterology, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan.
² Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine.
³ Division of Endoscopy, Shizuoka Cancer Center, Shizuoka, Japan; Department of Gastroenterology, Kanagawa Cancer Center, Kanagawa, Japan.
⁴ Department of Gastroenterology, Cancer Institute Hospital, Tokyo, Japan.
⁵ Department of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan; Department of Endoscopy and Endoscopic Surgery, Gunma University Hospital, Gunma, Japan.
⁶ Department of Gastroenterology, Kitasato University School of Medicine, Sagamihara, Japan.
⁷ Department of Gastroenterology, Toranomon Hospital, Tokyo, Japan.
⁸ Department of Gastroenterology and Endoscopy, National Cancer Center Hospital East, Kashiwa, Japan.
⁹ President, JA Onomichi General Hospital, Professor Emeritus, Hiroshima University, and Visiting Professor, Gastroenterology, Graduate School of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan.
¹⁰ Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Iwate Medical University, Yahaba, Japan.
¹¹ Department of Endoscopy, Hiroshima City Hiroshima Citizens Hospital, Hiroshima, Japan.
¹² Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
¹³ Department of Gastroenterology, Ishikawa Prefectural Central Hospital, Kanazawa, Japan.
¹⁴ Division of Endoscopy, Yokohama City University Medical Center, Yokohama, Japan.
¹⁵ Department of Gastroenterology, Toyama Prefectural Central Hospital, Toyama, Japan.
¹⁶ Department of Medicine, Division of Gastroenterology, Jichi Medical University, Tochigi, Japan.
¹⁷ Department of Gastroenterology, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan.
¹⁸ Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
¹⁹ Department of Gastroenterology, Japan Community Healthcare Organization Osaka Hospital, Osaka, Japan.
²⁰ Department of Gastroenterology, Tochigi Cancer Center, Utsunomiya, Japan; Endoscopy Division, National Cancer Center Hospital, Tokyo, Japan.
²¹ Department of Practical Gastrointestinal Endoscopy, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
²² Department of Internal Medicine, Keinan General Hospital, Niigata, Japan.
²³ Division of Behavioral Sciences, National Cancer Center Institute for Cancer Control, National Cancer Center, Tokyo, Japan.
²⁴ Division of Endoscopy, Shizuoka Cancer Center, Shizuoka, Japan.
²⁵ Department of Gastroenterology, Kitasato University School of Medicine, Sagamihara, Japan; Department of Gastroenterology, Ebina General Hospital, Ebina, Japan.
²⁶ Department of Gastroenterology, Tonan Hospital, Sapporo, Japan.
²⁷ Department of Gastroenterology, Itami City Hospital, Itami, Hyogo, Japan.
²⁸ Digestive Disease Center, Yuuai Medical Center, Okinawa, Japan.
²⁹ Endoscopy Division, National Cancer Center Hospital, Tokyo, Japan; Department of Internal Medicine, Kawasaki Rinko General Hospital, Kanagawa, Japan. Electronic address: ioda@ncc.go.jp.
³⁰ Division of Gastroenterology and Hepatology, Niigata University Medical and Dental Hospital, Niigata, Japan.
³¹ Department of Gastroenterology, Maztuzono 2nd Hospital, Morioka, Japan.
³² Department of Endoscopy, Saku Central Hospital Advanced Care Center, Nagano, Japan.
³³ Department of Gastroenterology, Tsuyama Chuo Hospital, Tsuyama, Japan.
³⁴ Department of Gastroenterological Oncology, Hyogo Cancer Center, Akashi, Japan.
³⁵ Department of Gastroenterology, Akita University Graduate School of Medicine and Koizumi Hospital, Akita, Japan.
³⁶ Department of Gastroenterology, National Hospital Organization Shikoku Cancer Center, Matuyama, Japan.
³⁷ Department of Endoscopy, Aichi Cancer Center Hospital, Nagoya, Japan.
³⁸ Department of Endoscopy, Fukushima Medical University Hospital, Fukushima, Japan.
³⁹ Department of Endoscopy, Fukuoka University Chikushi Hospital, Fukuoka, Japan.
⁴⁰ Department of Gastroenterology, National Center for Global Health and Medicine, Tokyo, Japan.
⁴¹ Department of Gastroenterology and Hepatology, Nagasaki University Hospital, Nagasaki, Japan.
⁴² Department of Gastroenterology, Ogaki Municipal Hospital, Ogaki, Japan.
⁴³ Department of Gastroenterology and Oncology, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.
⁴⁴ Chiyominomori General Medicine and Gastroenterology Clinic, Tottori, Japan.
⁴⁵ Department of Endoscopic Diagnostics and Therapeutics, Saga University Hospital, Saga, Japan.
⁴⁶ Department of Gastroenterology, Chofu Touzan Hospital, Tokyo, Japan.
⁴⁷ Department of Surgery, Kin-i-kyo Central Hospital, Sapporo, Japan.
⁴⁸ Department of Gastroenterology, Yamagata Prefectural Central Hospital, Yamagata, Japan.

PMID: 40210015
DOI: 10.1016/j.gie.2025.04.002

Abstract

Background and aims: There is limited evidence regarding the use of endoscopic resection for the treatment of gastric tube cancer. We investigated the short- and long-term outcomes of endoscopic resection in patients with gastric tube cancer and compared them with those with naïve stomach cancer.

Methods: This was a secondary analysis of data from a Japanese multicenter prospective cohort study. Data were extracted for all patients who underwent endoscopic resection for gastric tube cancer and naïve stomach cancer. The primary outcome measure was the 5-year overall survival (OS) after endoscopic resection.

Results: A total of 105 patients with gastric tube cancer (113 lesions) and 8460 patients with naïve stomach cancer (9394 lesions) were evaluated. Regarding short-term outcomes, there were no differences in adverse events between the 2 groups. The 5-year OS rate was significantly lower in patients with gastric tube cancer than in those with naïve stomach cancer (71.0% vs 89.5%; P < .001). Multivariate analysis of all-cause mortality revealed that the gastric tube cancer status was a significant factor for poorer OS. None of the patients with gastric tube cancer underwent additional surgery after noncurative resection.

Conclusions: Endoscopic resection could be safely performed for gastric tube cancer; however, its long-term prognosis is worse than that of naïve stomach cancer. Assessing various systemic conditions when deciding on a treatment strategy for gastric tube cancer is important.

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Conflict of interest statement

Disclosure All authors disclosed no financial relationships. This study was supported by a grant for Clinical Cancer Research from the Japanese Ministry of Health, Labour, and Welfare (H21-022), a grant from Daiwa Securities Health Foundation (H24-16), and grants for the National Cancer Center Research and Development from the Japanese Ministry of Health, Labour, and Welfare (25-A-12, 28-K-1, 29-A-13).

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Short- and long-term outcomes of endoscopic resection for gastric tube cancer: a Japanese multicenter prospective cohort study

Collaborators

Affiliations

Short- and long-term outcomes of endoscopic resection for gastric tube cancer: a Japanese multicenter prospective cohort study

Authors

Collaborators

Affiliations

Abstract

Conflict of interest statement

LinkOut - more resources

Full Text Sources