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Review
. 2025 Mar 20;28(3):201-212.
doi: 10.3779/j.issn.1009-3419.2025.106.06.

[Research Progress of Neutrophil Extracellular Traps in Lung Cancer]

[Article in Chinese]
Xu Hao  1 , Yilin Feng  1 , Anqi Lu  1 , Ying Sun  1 , Jinchan Xia  1 , Xue Mei  1 , Long Feng  1 , Min Jiang  1 , Baiyan Wang  1 , Huitong Yang  1
Affiliations
Review

[Research Progress of Neutrophil Extracellular Traps in Lung Cancer]

[Article in Chinese]
Xu Hao et al. Zhongguo Fei Ai Za Zhi. .

Abstract
in English, Chinese

Neutrophil extracellular traps (NETs), intricate reticular structures released by activated neutrophils, play a pivotal regulatory role in the pathogenesis of malignant tumors. Lung cancer is one of the most prevalent malignancies globally, with persistently high incidence and mortality rates. Recent studies have revealed that NETs dynamically modulate the tumor microenvironment through unique pathological mechanisms, exhibiting complex immunoregulatory characteristics during the progression of lung cancer, and this discovery has increasingly become a focal point in tumor immunology research. This paper provides a comprehensive review of the latest advancements in NETs research related to lung cancer, offering an in-depth analysis of their impact on lung cancer progression, their potential diagnostic value, and the current state of research on targeting NETs for lung cancer prevention and treatment. The aim is to propose novel strategies to enhance therapeutic outcomes and improve the prognosis for lung cancer patients. .

【中文题目：中性粒细胞胞外诱捕网在肺癌中的研究进展】 【中文摘要：中性粒细胞胞外诱捕网（neutrophil extracellular traps, NETs）作为中性粒细胞活化后释放的网状复合结构，在恶性肿瘤病理进程中发挥关键调控作用。肺癌是全球范围内最常见的恶性肿瘤之一，发病率和死亡率均居高不下。近年研究发现，NETs通过其独特的病理机制参与肿瘤微环境动态调控，在肺癌演进过程中呈现出复杂的免疫调节特征，这一发现已逐渐成为肿瘤免疫学研究的热点领域。本文系统地梳理了NETs在肺癌领域的最新研究进展，深度剖析了NETs对肺癌发生发展的影响和在肺癌诊断中的潜在价值，以及靶向NETs防治肺癌的研究现状，旨在为提高肺癌患者治疗疗效和改善预后提供新的思路。 】 【中文关键词：肿瘤相关中性粒细胞；中性粒细胞胞外诱捕网；肺肿瘤；肿瘤微环境】.

Keywords: Lung neoplasms; Neutrophil extracellular traps; Tumor associated neutrophils; Tumor microenvironment.

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Conflict of interest statement

Competing interests: The authors declare that thay have no competing interests.

Figures

Fig 1
图1. 中性粒细胞胞外诱捕网的生成机制
See this image and copyright information in PMC

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