Sedation, temperature and pressure after cardiac arrest and resuscitation-The STEPCARE trial: A statistical analysis plan

C B Kamp^{1

2}, J Dankiewicz³, M Harboe Olsen^{1

4}, J Holgersson⁵, M Saxena^{6

7}, P Young^{8

9

10

11}, V H Niemelä¹², J Hästbacka¹³, H Levin^{14

15}, G Lilja^{16

17}, M Moseby-Knappe^{14

16}, M Tiainen¹⁸, M Reinikainen^{19

20}, A Ceric²¹, J Johnsson²², J Undén^{23

24}, J Düring²¹, A Lybeck²⁴, D Rodriguez-Santos²⁵, A Lundin²⁶, J Kåhlin^{27

28}, J Grip^{27

29}, E Lotman³⁰, L Romundstad^{31

32}, P Seidel³³, P Stammet³⁴, T Graf^{35

36}, A Mengel^{37

38}, C Leithner³⁹, J Nee⁴⁰, P Drúwe⁴¹, K Ameloot⁴², M P Wise⁴³, P J McGuigan^{44

45}, A Ratcliffe⁴⁶, J Cole⁴⁷, J White⁴⁸, N Pareek^{49

50}, G Glover⁵¹, R Handslip⁵², A Proudfoot⁵³, M Thomas⁵⁴, D Pogson⁵⁵, T R Keeble^{56

57}, A Nichol^{58

59

60}, M Haenggi⁶¹, M P Hilty⁶¹, M Iten⁶², C Schrag⁶³, M Nafi⁶⁴, M Joannidis⁶⁵, C Robba^{66

67}, T Pellis⁶⁸, J Belohlavek^{69

70

71}, O Smid^{69

70}, D Rob^{69

70}, Y Arabi⁷², S Buabbas⁷³, C Yew Woon^{74

75

76}, Q Li⁷⁷, M Reade⁷⁸, A Delaney^{78

79

80}, B Venkatesh⁸¹, N Hammond^{79

82}, F Bass^{77

83}, A Aneman^{84

85

86}, A Stewart⁸⁷, L Navarra⁹, B Crichton⁹, D Knight⁸⁸, A Williams⁸⁹, J Tirkkonen⁹⁰, T Oksanen¹¹, T Kaakinen^{91

92}, S Bendel^{18

19}, H Friberg^{93

94}, T Cronberg^{15

16}, M B Skrifvars¹², N Nielsen^{5

94}, J C Jakobsen^{1

2}

Affiliations

¹ Copenhagen Trial Unit, Centre for Clinical Intervention Research, The Capital Region, Copenhagen University Hospital - Rigshospitalet, Copenhagen Ø, Denmark.
² Department of Regional Health Research, The Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark.
³ Department of Clinical Sciences Lund, Section of Cardiology, Skåne University Hospital, Scania, Sweden.
⁴ Department of Neuroanaesthesiology, The Neuroscience Centre, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
⁵ Anesthesiology and Intensive Care, Department of Clinical Sciences, Helsingborg Hospital Lund, Lund University, Lund, Sweden.
⁶ Critical Care Division and Department of Intensive Care Medicine, The George Institute for Global Health, Sydney, NSW, Australia.
⁷ St George Hospital Clinical School, University of New South Wales, Sydney, Australia.
⁸ Intensive Care Unit, Wellington Hospital, Wellington, New Zealand.
⁹ Medical Research Institute of New Zealand, Wellington, New Zealand.
¹⁰ Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, Victoria, Australia.
¹¹ Department of Critical Care, University of Melbourne, Melbourne, Victoria, Australia.
¹² Department of Anaesthesia and Intensive Care, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
¹³ Tampere University Hospital, Wellbeing Services County of Pirkanmaa and Tampere University, Faculty of Medicine and Health Technology, Tampere, Finland.
¹⁴ Department of Clinical Sciences Lund, Lund University, Lund, Sweden.
¹⁵ Department of Research, Development, Education and Innovation, Skåne University Hospital, Lund, Sweden.
¹⁶ Department of Neurology and Rehabilitation, Skåne University Hospital, Lund, Sweden.
¹⁷ Neurology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.
¹⁸ Department of Neurology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
¹⁹ University of Eastern Finland, Institute of Clinical Medicine, Finland.
²⁰ Department of Anaesthesiology and Intensive Care, Kuopio University Hospital, Finland.
²¹ Anaesthesia & Intensive Care, Department of Clinical Sciences, Lund University, Skåne University Hospital, Malmö, Sweden.
²² Department of Anaesthesiology and Intensive Care, Helsingborg Hospital, Helsingborg, Sweden.
²³ Department of Operation and Intensive Care, Hallands Hospital Halmstad, Sweden.
²⁴ Department of Intensive and Perioperative Care, Skåne University Hospital, Lund University, Lund, Sweden.
²⁵ Department of Anaesthesia and Intensive Care, Skaraborgs Sjukhus, Skövde, Sweden.
²⁶ Department of Anaesthesiology and Intensive Care Medicine, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
²⁷ Perioperative Medicine and Intensive Care (PMI), Karolinska University Hospital, Stockholm, Sweden.
²⁸ Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden.
²⁹ Department of Clinical Science, Intervention and Technology, Karolinska Institute, Stockholm, Sweden.
³⁰ North Estonia Medical Centre, Estonia.
³¹ Department of Anaesthesia and Intensive Care Medicine, Division of Emergencies and Critical Care, Oslo University Hospital, Oslo, Norway.
³² Lovisenberg Diaconal University College, Oslo, Norway.
³³ Department of Intensive Care Medicine, Stavanger University Hospital, Stavanger, Norway.
³⁴ Department of Anaesthesia and Intensive Care Medicine, Centre Hospitalier de Luxembourg, Luxembourg, Luxembourg.
³⁵ University Heart Center Lübeck, University Hospital Schleswig-Holstein, Germany.
³⁶ German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Lübeck/Kiel, Germany.
³⁷ Department of Neurology and Stroke, University Hospital Tuebingen, Germany.
³⁸ Hertie Institute of Clinical Brain Research, Germany.
³⁹ Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität and Humboldt-Universität zu Berlin, Department of Neurology, Berlin, Germany.
⁴⁰ Department of Nephrology and Medical Intensive Care, Charité - Universitaetsmedizin Berlin, Berlin, Germany.
⁴¹ Department of Intensive Care Medicine, Ghent University Hospital, Ghent, Belgium.
⁴² Department of Cardiology, Ziekenhuis Oost-Limburg, Genk, Belgium.
⁴³ Adult Critical Care, University Hospital of Wales, Cardiff, UK.
⁴⁴ Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, UK.
⁴⁵ Regional Intensive Care Unit, Royal Victoria Hospital, Belfast, UK.
⁴⁶ Leeds General Infirmary, The Leeds Teaching Hospitals NHS Trust, Leeds, UK.
⁴⁷ Critical Care, University Hospital of Wales, Cardiff, UK.
⁴⁸ Centre for Healthcare Evaluation, Device Assessment and Research, Cardiff and Vale University, Health Board, Cardiff, UK.
⁴⁹ Department of Cardiology, King's College Hospital NHS Foundation Trust, London, UK.
⁵⁰ School of Cardiovascular and Metabolic Medicine & Sciences, BHF Centre of Excellence, King's College London, UK.
⁵¹ Department of Critical Care, Guy's and St Thomas NHS Foundation Trust, London, UK.
⁵² St George's University Hospital NHS Foundation Trust, London, UK.
⁵³ Department of Perioperative Medicine, Barts Heart Centre, St Bartholomew's Hospital, London, UK.
⁵⁴ University Hospitals, Bristol and Weston, UK.
⁵⁵ Department of Critical Care, Portsmouth University Hospitals Trust, Portsmouth, UK.
⁵⁶ Essex Cardiothoracic Centre, MSE NHSFT, Essex, UK.
⁵⁷ Anglia Ruskin School of Medicine & MTRC, ARU, Essex, UK.
⁵⁸ University College Dublin Clinical Research Centre at St Vincent's University Hospital, University College Dublin, Dublin, Ireland.
⁵⁹ The Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, Australia.
⁶⁰ The Alfred Hospital, Melbourne, Australia.
⁶¹ Institute of Intensive Care Medicine University Hospital Zurich, Zurich, Switzerland.
⁶² Department of Intensive Care Medicine, Inselspital University Hospital Bern, Bern, Switzerland.
⁶³ Klinik für Intensivmedizin, Kantonsspital St. Gallen, St. Gallen, Switzerland.
⁶⁴ Istituto Cardiocentro Ticino Lugano, Switzerland.
⁶⁵ Division of Intensive Care and Emergency Medicine, Department of Internal Medicine, Medical University Insbruck, Innsbruck, Austria.
⁶⁶ IRCCS Policlinico San Martino, Genova, Italy.
⁶⁷ Dipartimento di Scienze Chirurgiche Diagnostiche Integrate, University of Genova, Italy.
⁶⁸ Anaesthesia and Intensive Care, Pordenone Hospital Azienda Sanitaria Friuli Occidentale, Italy.
⁶⁹ 2nd Department of Internal Medicine, Cardiovascular Medicine, General University Hospital, Prague, Czech Republic.
⁷⁰ 1st Faculty of Medicine, Charles University, Prague, Czech Republic.
⁷¹ Institute for Heart Diseases, Wroclaw Medical University, Wrocław, Poland.
⁷² King Saud bin Abdulaziz University for Health Sciences and King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.
⁷³ Department of Anaesthesia, Critical Care and Pain Medicine, Jaber Alahmad Alsabah Hospital, Kuwait.
⁷⁴ Tan Tock Seng Hospital, Singapore, Singapore.
⁷⁵ Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
⁷⁶ Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
⁷⁷ The George Institute for Global Health, University of New South Wales, Sydney, Australia.
⁷⁸ Medical School, University of Queensland, Brisbane, Australia.
⁷⁹ Malcolm Fisher Department of Intensive Care Medicine, Royal North Shore Hospital, St Leonards, Australia.
⁸⁰ Northern Clinical School, Sydney Medical School, University of Sydney, Camperdown, New South Wales, Australia.
⁸¹ The George Institute for Global Health, Sydney, New South Wales, Australia.
⁸² Critical Care Program, The George Institute for Global Health, UNSW, Sydney, Australia.
⁸³ Royal North Shore Hospital, Sydney, Australia.
⁸⁴ Intensive Care Unit, Liverpool Hospital, South Western Sydney Local Health District, Sydney, New South Wales, Australia.
⁸⁵ South Western Clinical School, University of New South Wales, Sydney, New South Wales, Australia.
⁸⁶ The Ingham Institute for Applied Medical Research, Sydney, New South Wales, Australia.
⁸⁷ Liverpool Hospital, South Western Sydney Local Health District, Liverpool, New South Wales, Australia.
⁸⁸ Department of Intensive Care, Christchurch Hospital, New Zealand.
⁸⁹ Middlemore Hospital, Auckland, New Zealand.
⁹⁰ Intensive Care Unit, Tampere University Hospital, Finland.
⁹¹ Research Unit of Translational Medicine, Research Group of Anaesthesiology, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.
⁹² OYS Heart, Oulu University Hospital, MRC Oulu and University of Oulu, Oulu, Finland.
⁹³ Intensive and Perioperative Care, Skåne University Hospital, Malmö, Sweden.
⁹⁴ Anesthesia and Intensive Care, Department of Clinical Sciences Lund, Lund University, Sweden.

PMID: 40210585
PMCID: PMC11985327
DOI: 10.1111/aas.70033

Multicenter Study

Sedation, temperature and pressure after cardiac arrest and resuscitation-The STEPCARE trial: A statistical analysis plan

C B Kamp et al. Acta Anaesthesiol Scand. 2025 May.

. 2025 May;69(5):e70033.

doi: 10.1111/aas.70033.

Authors

Affiliations

¹ Copenhagen Trial Unit, Centre for Clinical Intervention Research, The Capital Region, Copenhagen University Hospital - Rigshospitalet, Copenhagen Ø, Denmark.
² Department of Regional Health Research, The Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark.
³ Department of Clinical Sciences Lund, Section of Cardiology, Skåne University Hospital, Scania, Sweden.
⁴ Department of Neuroanaesthesiology, The Neuroscience Centre, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
⁵ Anesthesiology and Intensive Care, Department of Clinical Sciences, Helsingborg Hospital Lund, Lund University, Lund, Sweden.
⁶ Critical Care Division and Department of Intensive Care Medicine, The George Institute for Global Health, Sydney, NSW, Australia.
⁷ St George Hospital Clinical School, University of New South Wales, Sydney, Australia.
⁸ Intensive Care Unit, Wellington Hospital, Wellington, New Zealand.
⁹ Medical Research Institute of New Zealand, Wellington, New Zealand.
¹⁰ Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, Victoria, Australia.
¹¹ Department of Critical Care, University of Melbourne, Melbourne, Victoria, Australia.
¹² Department of Anaesthesia and Intensive Care, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
¹³ Tampere University Hospital, Wellbeing Services County of Pirkanmaa and Tampere University, Faculty of Medicine and Health Technology, Tampere, Finland.
¹⁴ Department of Clinical Sciences Lund, Lund University, Lund, Sweden.
¹⁵ Department of Research, Development, Education and Innovation, Skåne University Hospital, Lund, Sweden.
¹⁶ Department of Neurology and Rehabilitation, Skåne University Hospital, Lund, Sweden.
¹⁷ Neurology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.
¹⁸ Department of Neurology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
¹⁹ University of Eastern Finland, Institute of Clinical Medicine, Finland.
²⁰ Department of Anaesthesiology and Intensive Care, Kuopio University Hospital, Finland.
²¹ Anaesthesia & Intensive Care, Department of Clinical Sciences, Lund University, Skåne University Hospital, Malmö, Sweden.
²² Department of Anaesthesiology and Intensive Care, Helsingborg Hospital, Helsingborg, Sweden.
²³ Department of Operation and Intensive Care, Hallands Hospital Halmstad, Sweden.
²⁴ Department of Intensive and Perioperative Care, Skåne University Hospital, Lund University, Lund, Sweden.
²⁵ Department of Anaesthesia and Intensive Care, Skaraborgs Sjukhus, Skövde, Sweden.
²⁶ Department of Anaesthesiology and Intensive Care Medicine, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
²⁷ Perioperative Medicine and Intensive Care (PMI), Karolinska University Hospital, Stockholm, Sweden.
²⁸ Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden.
²⁹ Department of Clinical Science, Intervention and Technology, Karolinska Institute, Stockholm, Sweden.
³⁰ North Estonia Medical Centre, Estonia.
³¹ Department of Anaesthesia and Intensive Care Medicine, Division of Emergencies and Critical Care, Oslo University Hospital, Oslo, Norway.
³² Lovisenberg Diaconal University College, Oslo, Norway.
³³ Department of Intensive Care Medicine, Stavanger University Hospital, Stavanger, Norway.
³⁴ Department of Anaesthesia and Intensive Care Medicine, Centre Hospitalier de Luxembourg, Luxembourg, Luxembourg.
³⁵ University Heart Center Lübeck, University Hospital Schleswig-Holstein, Germany.
³⁶ German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Lübeck/Kiel, Germany.
³⁷ Department of Neurology and Stroke, University Hospital Tuebingen, Germany.
³⁸ Hertie Institute of Clinical Brain Research, Germany.
³⁹ Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität and Humboldt-Universität zu Berlin, Department of Neurology, Berlin, Germany.
⁴⁰ Department of Nephrology and Medical Intensive Care, Charité - Universitaetsmedizin Berlin, Berlin, Germany.
⁴¹ Department of Intensive Care Medicine, Ghent University Hospital, Ghent, Belgium.
⁴² Department of Cardiology, Ziekenhuis Oost-Limburg, Genk, Belgium.
⁴³ Adult Critical Care, University Hospital of Wales, Cardiff, UK.
⁴⁴ Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, UK.
⁴⁵ Regional Intensive Care Unit, Royal Victoria Hospital, Belfast, UK.
⁴⁶ Leeds General Infirmary, The Leeds Teaching Hospitals NHS Trust, Leeds, UK.
⁴⁷ Critical Care, University Hospital of Wales, Cardiff, UK.
⁴⁸ Centre for Healthcare Evaluation, Device Assessment and Research, Cardiff and Vale University, Health Board, Cardiff, UK.
⁴⁹ Department of Cardiology, King's College Hospital NHS Foundation Trust, London, UK.
⁵⁰ School of Cardiovascular and Metabolic Medicine & Sciences, BHF Centre of Excellence, King's College London, UK.
⁵¹ Department of Critical Care, Guy's and St Thomas NHS Foundation Trust, London, UK.
⁵² St George's University Hospital NHS Foundation Trust, London, UK.
⁵³ Department of Perioperative Medicine, Barts Heart Centre, St Bartholomew's Hospital, London, UK.
⁵⁴ University Hospitals, Bristol and Weston, UK.
⁵⁵ Department of Critical Care, Portsmouth University Hospitals Trust, Portsmouth, UK.
⁵⁶ Essex Cardiothoracic Centre, MSE NHSFT, Essex, UK.
⁵⁷ Anglia Ruskin School of Medicine & MTRC, ARU, Essex, UK.
⁵⁸ University College Dublin Clinical Research Centre at St Vincent's University Hospital, University College Dublin, Dublin, Ireland.
⁵⁹ The Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, Australia.
⁶⁰ The Alfred Hospital, Melbourne, Australia.
⁶¹ Institute of Intensive Care Medicine University Hospital Zurich, Zurich, Switzerland.
⁶² Department of Intensive Care Medicine, Inselspital University Hospital Bern, Bern, Switzerland.
⁶³ Klinik für Intensivmedizin, Kantonsspital St. Gallen, St. Gallen, Switzerland.
⁶⁴ Istituto Cardiocentro Ticino Lugano, Switzerland.
⁶⁵ Division of Intensive Care and Emergency Medicine, Department of Internal Medicine, Medical University Insbruck, Innsbruck, Austria.
⁶⁶ IRCCS Policlinico San Martino, Genova, Italy.
⁶⁷ Dipartimento di Scienze Chirurgiche Diagnostiche Integrate, University of Genova, Italy.
⁶⁸ Anaesthesia and Intensive Care, Pordenone Hospital Azienda Sanitaria Friuli Occidentale, Italy.
⁶⁹ 2nd Department of Internal Medicine, Cardiovascular Medicine, General University Hospital, Prague, Czech Republic.
⁷⁰ 1st Faculty of Medicine, Charles University, Prague, Czech Republic.
⁷¹ Institute for Heart Diseases, Wroclaw Medical University, Wrocław, Poland.
⁷² King Saud bin Abdulaziz University for Health Sciences and King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.
⁷³ Department of Anaesthesia, Critical Care and Pain Medicine, Jaber Alahmad Alsabah Hospital, Kuwait.
⁷⁴ Tan Tock Seng Hospital, Singapore, Singapore.
⁷⁵ Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
⁷⁶ Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
⁷⁷ The George Institute for Global Health, University of New South Wales, Sydney, Australia.
⁷⁸ Medical School, University of Queensland, Brisbane, Australia.
⁷⁹ Malcolm Fisher Department of Intensive Care Medicine, Royal North Shore Hospital, St Leonards, Australia.
⁸⁰ Northern Clinical School, Sydney Medical School, University of Sydney, Camperdown, New South Wales, Australia.
⁸¹ The George Institute for Global Health, Sydney, New South Wales, Australia.
⁸² Critical Care Program, The George Institute for Global Health, UNSW, Sydney, Australia.
⁸³ Royal North Shore Hospital, Sydney, Australia.
⁸⁴ Intensive Care Unit, Liverpool Hospital, South Western Sydney Local Health District, Sydney, New South Wales, Australia.
⁸⁵ South Western Clinical School, University of New South Wales, Sydney, New South Wales, Australia.
⁸⁶ The Ingham Institute for Applied Medical Research, Sydney, New South Wales, Australia.
⁸⁷ Liverpool Hospital, South Western Sydney Local Health District, Liverpool, New South Wales, Australia.
⁸⁸ Department of Intensive Care, Christchurch Hospital, New Zealand.
⁸⁹ Middlemore Hospital, Auckland, New Zealand.
⁹⁰ Intensive Care Unit, Tampere University Hospital, Finland.
⁹¹ Research Unit of Translational Medicine, Research Group of Anaesthesiology, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.
⁹² OYS Heart, Oulu University Hospital, MRC Oulu and University of Oulu, Oulu, Finland.
⁹³ Intensive and Perioperative Care, Skåne University Hospital, Malmö, Sweden.
⁹⁴ Anesthesia and Intensive Care, Department of Clinical Sciences Lund, Lund University, Sweden.

PMID: 40210585
PMCID: PMC11985327
DOI: 10.1111/aas.70033

Abstract

Background: Basic management for patients who have suffered a cardiac arrest and are admitted to an intensive care unit (ICU) after resuscitation includes setting targets for blood pressure and managing sedation and temperature. However, optimal targets and management are unknown.

Methods: The STEPCARE (Sedation, Temperature and Pressure after Cardiac Arrest and Resuscitation) trial is a multicenter, parallel-group, randomized, factorial, superiority trial in which sedation, temperature, and blood pressure strategies will be studied in three separate comparisons (SED-CARE, TEMP-CARE, and MAP-CARE). The trial population will be adults admitted to intensive care who are comatose after resuscitation from out-of-hospital cardiac arrest. The primary outcome will be all-cause mortality, and the secondary outcomes will be poor functional outcome (modified Rankin Scale 4-6), Health-Related Quality of Life using EQ-VAS, and specific serious adverse events in the intensive care unit predefined for each trial. All outcomes will be assessed at 6 months after randomization. The prognosticators, outcome assessors, statisticians, data managers, steering group, and manuscript writers will be blinded to treatment allocation. This statistical analysis plan includes a comprehensive description of the statistical analyses, handling of missing data, and assessments of underlying statistical assumptions. Analyses will be conducted according to the intention-to-treat principle, that is, all randomized participants with available data will be included. The analyses will be performed independently by two statisticians following the present plan.

Conclusion: This statistical analysis plan describes the statistical analyses for the STEPCARE trial in detail. The aim of this predefined statistical analysis plan is to minimize the risk of analysis bias.

Keywords: STEPCARE trial; blood pressure; cardiac arrest; sedation; statistical analysis; temperature.

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Conflict of interest statement

Pellis T. received lecture fees from BD. Leithner C received research support from Laerdal Foundation. Glover G received consulting and speaker fees from Sedana Medical; BD; and research grants from Mindray and Sedana Medical. Nee J received honorarium and travel costs for presentations from BD BARD and Xenios AG. Pareek N received Abbott Vascular—Honoraria, Consultancy, Educational Grants, and NIPRO—Honoraria, Shockwave Medical—Consultancy. Skrifvars M received a speaker's fee from BARD Medical (Ireland) 2022 and he is a member of the editorial board of Acta Anaesthesiologica Scandinavica.

References

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Sedation, temperature and pressure after cardiac arrest and resuscitation-The STEPCARE trial: A statistical analysis plan

Affiliations

Sedation, temperature and pressure after cardiac arrest and resuscitation-The STEPCARE trial: A statistical analysis plan

Authors

Affiliations

Abstract

Conflict of interest statement

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Medical