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. 2025 Apr 11;10(1):110.
doi: 10.1038/s41392-025-02205-y.

Adiponectin to the rescue: extracorporeal photopheresis for managing immune checkpoint inhibitor-induced toxicities

Robin Reschke  1   2 , Alexander H Enk  3 , Jessica C Hassel  3   4
Affiliations

Adiponectin to the rescue: extracorporeal photopheresis for managing immune checkpoint inhibitor-induced toxicities

Robin Reschke et al. Signal Transduct Target Ther. .
No abstract available

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Conflict of interest statement

Competing interests: R.R. has received travel expenses from Sunpharma. J.C.H. has received honoraria from Amgen, BMS, Delcath, GSK, MSD, Novartis, Pierre Fabre, Roche, Sanofi and Sunpharma; has served as a consultant or advisor for GSK, MSD, Pierre Fabre, Sunpharma, Immunocore, Nektar, Novartis, Philogen, Sanofi, BMS, Sunpharma and Sanofi; and has received research funding or support for clinical studies from BMS, Sunpharma, Sanofi, AstraZeneca, BioNTech, BMS, Genentech/Roche, Genmab, Idera, Immunocore, IOBiotech, Iovance, Nektar, Novartis, Philogen, Pierre Fabre, Regeneron, Replimune, Sanofi, and Seagen. A.H.E. received honoraria by Janssen-Cilag, Biotest, MSD and Galderma. A.H.E. is president of the European Dermatology Forum (EDF).

Figures

Fig. 1
Fig. 1
Schematic representation of ECP’s effect on immune cells and intestinal irAEs. ECP induces leukocyte apoptosis, followed by their phagocytosis by macrophages. Signal transducer and activator of transcription 6 (STAT6) is phosphorylated and induces Arginase-1 (ARG1), CD206, CD301 and peroxisome proliferator-activated receptor gamma (PPARγ) in macrophages. These macrophages adopt an M2-like phenotype produce adiponectin. Consequently, tissue-resident memory T cells (TRMs), Th1, Tc1, pathogenic CD25high T cells and neutrophils are downregulated. Conversely, regulatory T cells (Tregs) are downregulated. The immunological changes lead to the resolution of irAE-associated inflammation in the gastrointestinal tract. ECP: extracorporeal photopheresis. (figure created with BioRender.com)
See this image and copyright information in PMC

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References

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