Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2025 Apr 10;25(1):1347.
doi: 10.1186/s12889-025-22594-7.

The role of lipid profile in the relationship between skipping breakfast and hyperuricemia: a moderated mediation model

Zhihao Deng  1 , Feixiang Zhou  1 , Gang Tian  2 , Qi Wang  1 , Yan Yan  3
Affiliations

The role of lipid profile in the relationship between skipping breakfast and hyperuricemia: a moderated mediation model

Zhihao Deng et al. BMC Public Health. .

Abstract

Background: The prevalence of hyperuricemia is rising among oilfield workers in China. This study aimed to explore the underlying mechanisms between skipping breakfast and serum uric acid.

Methods: A total of 21,676 participants aged 20--60 from a large oilfield company in China were included. Association analysis, multivariate logistic, subgroup analysis, and moderated mediation analysis were performed to assess the association between skipping breakfast and hyperuricemia.

Results: We found that 24.48% of oilfield employees had hyperuricemia. The odds ratio of hyperuricemia linked to skipping breakfast was 0.78 (95%CI: 0.69--0.88). The association between skipping breakfast and hyperuricemia was mediated by TC (22.32%) and LDL-C (21.57%). Age moderated this mediation, with significant effects for skipping breakfast (ß: 0.553, 95%CI: 0.042--1.063) and TC (ß: -0.339, 95%CI: -0.586- -0.093). Similar results were observed for LDL-C mediation (ß: 0.522, 95%CI: 0.009--1.035; ß: -0.585, 95%CI: -0.894- -0.276).

Conclusion: Skipping breakfast positively influenced hyperuricemia through TC and LDL-C. Age moderated the relationship between skipping breakfast and serum uric acid. Greater attention should be given to young employees in Chinese oilfield enterprises, with dietary interventions implemented to reduce abnormal lipids metabolism and hyperuricemia.

Keywords: Age; Breakfast; Hyperuricemia; Lipid profile; Working population.

PubMed Disclaimer

Conflict of interest statement

Declarations. Ethics approval and consent to participate: This project has been approved by the Ethics Committee of Xiangya School of Public Health, Central South University (Approval No.: XYGW-2023-92) and conducted in accordance with the Declaration of Helsinki. All participants were asked to provide written informed consent before completing the survey. All procedures followed the relevant ethical guidelines and regulations. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Model of the moderating role of age on the direct and indirect relationship between skipping breakfast and SUA through A (TC) and B (LDL-C) Notes. TC, Total Cholesterol; LDL-C, Low-Density Lipoprotein Cholesterol; SUA, Serum Uric Acid; Values are unstandardized coefficients; Level of confidence: 95%; * P < 0.05, ** P < 0.01, *** P < 0.001 (2–tailed)
Fig. 2
Fig. 2
Moderating effect of age on the relationship between A (TC), B (skipping breakfast; M: TC), C (LDL-C), D (skipping breakfast; M: LDL-C) and SUA Notes. TC, Total Cholesterol; LDL-C, Low-Density Lipoprotein Cholesterol; SUA, Serum Uric Acid; SD: Standard Deviations
See this image and copyright information in PMC

References

    1. Han Y, Cao Y, Han X, Di H, Yin Y, Wu J, Zhang Y, Zeng X. Hyperuricemia and gout increased the risk of long-term mortality in patients with heart failure: insights from the National health and nutrition examination survey. J Transl Med. 2023;21(1):463. - DOI - PMC - PubMed
    1. Zhang J, Jin C, Ma B, Sun H, Chen Y, Zhong Y, Han C, Liu T, Li Y. Global, regional and National burdens of gout in the young population from 1990 to 2019: a population-based study. RMD Open 2023, 9(2). - PMC - PubMed
    1. Li Y, Shen Z, Zhu B, Zhang H, Zhang X, Ding X. Demographic, regional and Temporal trends of hyperuricemia epidemics in Mainland China from 2000 to 2019: a systematic review and meta-analysis. Glob Health Action. 2021;14(1):1874652. - DOI - PMC - PubMed
    1. Ting K, Gill TK, Keen H, Tucker GR, Hill CL. Prevalence and associations of gout and hyperuricaemia: results from an Australian population-based study. Intern Med J. 2016;46(5):566–73. - DOI - PubMed
    1. Chen-Xu M, Yokose C, Rai SK, Pillinger MH, Choi HK. Contemporary prevalence of gout and hyperuricemia in the united States and decadal trends: the National health and nutrition examination survey, 2007–2016. Arthritis Rheumatol. 2019;71(6):991–9. - DOI - PMC - PubMed

LinkOut - more resources