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Review
. 2025 Apr-Jun;18(2):78-85.
doi: 10.25259/jcas_182_23. Epub 2024 Sep 6.

Bicalutamide: A review

Shayna Aulakh  1 , Venkataram Mysore  1
Affiliations
Review

Bicalutamide: A review

Shayna Aulakh et al. J Cutan Aesthet Surg. 2025 Apr-Jun.

Abstract

Bicalutamide is a non-steroidal androgen receptor antagonist that exerts anti-androgenic effects on peripheral tissues. It has been recently of interest in female pattern hair loss and has led to the off-label use of this drug for the improvement of Sinclair grading in such patients. This review aims to discuss the pharmacological properties along with indications, contraindications, and safety profile of bicalutamide for its use in dermatological research.

Keywords: Alopecia; Androgen Receptor; Anti-androgen drug; Bicalutamide; Female pattern hair loss.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1:
Figure 1:
Classification of anti-androgen therapies. GnRH: Gonadotropin-releasing hormone. *Name of compounds(drugs) under the pharmaceutical classes
Figure 2:
Figure 2:
Chemical structure of bicalutamide. NC: Cyano group, F3C: Trifluoromethyl group, SO2: Sulfonyl group, OH: Hydroxy group, NH: amide group.
See this image and copyright information in PMC

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