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. 2025 Apr 10;15(15):11370-11376.
doi: 10.1039/d5ra00743g. eCollection 2025 Apr 9.

The organophotocatalytic trifluoromethylation of 6-azauracils

Krishna Kanta Das  1 , Alakananda Hajra  1
Affiliations

The organophotocatalytic trifluoromethylation of 6-azauracils

Krishna Kanta Das et al. RSC Adv. .

Abstract

An efficient, cost-effective, and metal-free photocatalytic trifluoromethylation of 6-azauracils has been developed using Langlois reagent (CF3SO2Na) under ambient air. The present protocol, which utilizes an inexpensive CF3 reagent and an organophotocatalyst, provides a convenient way to prepare trifluoromethylated azauracil derivatives with a variety of functional groups. The experimental results suggest a radical mechanistic pathway for this methodology.

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Conflict of interest statement

There are no conflicts of interest to declare.

Figures

Fig. 1
Fig. 1. Bioactive molecules containing azauracil scaffolds.
Scheme 1
Scheme 1. The direct trifluoromethylation of 6-azauracils.
Scheme 2
Scheme 2. Scaled-up and control experiments.
Scheme 3
Scheme 3. A plausible mechanistic pathway.
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