Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2025 Jun 1;21(4):226-239.
doi: 10.1097/PTS.0000000000001345. Epub 2025 Apr 14.

Development and Evaluation of a Multifaceted Intervention Program for Preventing Medication Administration Errors by Nurses

Won Hee Sim  1
Affiliations

Development and Evaluation of a Multifaceted Intervention Program for Preventing Medication Administration Errors by Nurses

Won Hee Sim. J Patient Saf. .

Abstract

Objective: This study aimed to develop and evaluate a multifaceted intervention program based on the Systems Engineering Initiatives for Patient Safety (SEIPS) model to prevent medication administration errors (MAEs) by nurses in an adult general ward of a comprehensive hospital in Seoul, South Korea.

Methods: The program was developed using the Analysis, Design, Development, Implementation, Evaluation (ADDIE) model with a 3-round Delphi survey conducted with 16 experts. Strategies were categorized under the SEIPS model and finalized into a program with 9 domains and 21 interventions. A pretest-posttest design with 73 nurses (36 experimental, 37 control) evaluated the program's effectiveness in a tertiary care hospital in Seoul, South Korea. Surveys on patient safety culture, medication safety practices, and error rates were analyzed before and after a 3-month intervention using double-difference and time-series methods.

Results: The DID analysis demonstrated significant improvements in patient safety culture perception (0.42, P <0.001) and medication safety compliance (0.53, P <0.001), with large effect sizes ( d =1.07 and d =1.41, respectively). However, changes in self-reported medication error rates between groups were not statistically significant ( P =0.555), likely due to the short intervention period.

Conclusion: The program improved patient safety awareness and medication safety compliance, validating its approach. This study highlights the importance of theoretically based interventions and suggests shifting from solely nurse education to addressing systemic issues for medication safety.

Keywords: medication errors; nurses; patient safety; program development; safety management.

PubMed Disclaimer

Conflict of interest statement

The author discloses no conflict of interest.

Figures

FIGURE 1
FIGURE 1
Conceptual framework of the study based on SEIPS model.
FIGURE 2
FIGURE 2
Research procedure.
FIGURE 3
FIGURE 3
Results of interrupted time series analysis with nonequivalent control group design on medication error reporting rate.
See this image and copyright information in PMC

References

    1. National Coordinating Council for Medication Error Reporting and Prevention . About Medication errors. Accessed December 28, 2022. https://www.nccmerp.org/about-medication-errors
    1. Airaksinen M, Otero MJ, Schmitt E, et al. . Creation of a Better Medication Safety Culture in Europe: Building up Safe Medication Practices. France: Council of Europe; 2007.
    1. Tariq RA, Vashisht R, Sinha A, et al. . Medication Dispensing Errors and Prevention. Florida, USA: StatPearls Publishing; 2022. https://europepmc.org/article/NBK/nbk519065#impact - PubMed
    1. Korea Institute for Healthcare Accreditation . Korean Patient Safety Incident Report 2022. Korea Institute for Healthcare Accreditation; 2023. Accessed September 12, 2023. https://www.kops.or.kr/portal/board/statAnlrpt/boardDetail.do
    1. Donaldson LJ, Kelley ET, Dhingra-Kumar N, et al. . Medication without harm: WHO’s third global patient safety challenge. Lancet. 2017;389:1680–1681. - PubMed