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. 2025 Sep 1;74(9):1525-1534.
doi: 10.2337/db24-1071.

GLP-1-Mediated Targeting of Inflammation Corrects Obesogenic Memory in Male Mice

Stéphane Léon  1 , Julie Benoit  1 , Samantha Clark  1 , Philippe Zizzari  1 , Bin Yang  2 , Isabelle Dugail  3 , Fatiha Merabtene  3 , Karine Clément  3   4 , Louise Eygret  1 , Nathalie Dupuy  1 , Jean-Christophe Delpech  5 , Moïra Rossitto  5 , Matthias Mack  6 , Thierry Lesté-Lasserre  1 , Brian Finan  7 , Daniela Cota  1 , Carmelo Quarta  1
Affiliations

GLP-1-Mediated Targeting of Inflammation Corrects Obesogenic Memory in Male Mice

Stéphane Léon et al. Diabetes. .

Abstract

Weight loss defense mechanisms and inflammation challenge metabolic disease management, with few treatments available. We developed a mouse model of obesogenic memory and investigated the efficacy of a glucagon-like peptide 1/dexamethasone (GLP-1/Dexa) conjugate that safely and cell-selectively targets inflammation in GLP-1 receptor cells. GLP-1/Dexa offers a promising strategy to correct obesogenic memory and adipose tissue inflammation in male mice. CCR2 monocytes contribute to glucose intolerance associated with obesogenic memory and may be targeted by GLP-1/Dexa.

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