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Review
. 2025 Apr 11.
doi: 10.1038/s41372-025-02289-y. Online ahead of print.

Considerations for obstetric management of births 22-25 weeks' gestation

Felicia V LeMoine  1 , Ashley N Battarbee  2 , Colm P Travers  3 , Cheryl Battersby  4   5 , Kelly S Gibson  6 ; Tiny Baby Collaborative Steering Committee
Collaborators, Affiliations
Review

Considerations for obstetric management of births 22-25 weeks' gestation

Felicia V LeMoine et al. J Perinatol. .

Abstract

Preterm birth between 22 and 25 5/7 weeks complicates <1% of live births within the United States though contributes more than 20% of infant mortality within the first year of life. Ante- and intrapartum interventions such as antenatal corticosteroids, magnesium sulfate, and tocolytic and antibiotic therapies have been shown effective in optimizing postnatal prognosis in births at 24 weeks and beyond. Interventions, mode of delivery, and resuscitation plans should ideally be discussed with the perinatology, neonatology, and nursing teams with the family using shared decision making. Observational data have alluded to similar postnatal benefits in births at 22-23 weeks; however, these data are limited by small sample sizes, inconsistencies in outcome reporting, and variations in management strategies. Future studies to evaluate the utility of these interventions among births at 22-23 weeks are warranted.

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Conflict of interest statement

Competing interests: The authors declare no competing interests.

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