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. 2025 Jun;39(6):1516-1519.
doi: 10.1038/s41375-025-02602-w. Epub 2025 Apr 11.

All genetic subtypes of B-cell acute lymphoblastic leukemia exhibit increased incidence rates in children with Down syndrome

Ching-Ju Hsu  1 , Jeremy M Schraw  1 , Tania A Desrosiers  2 , Amanda E Janitz  3 , Russell S Kirby  4 , Eirini Nestoridi  5 , Wendy N Nembhard  6 , Jason L Salemi  4 , Charles Shumate  7 , Jean Paul Tanner  4 , Mahsa M Yazdy  5 , Michael E Scheurer  1 , Karen R Rabin #  8 , Philip J Lupo #  9
Affiliations

All genetic subtypes of B-cell acute lymphoblastic leukemia exhibit increased incidence rates in children with Down syndrome

Ching-Ju Hsu et al. Leukemia. 2025 Jun.
No abstract available

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Conflict of interest statement

Competing interests: The authors declare no competing interests. Ethics approval and consent to participate: This study complied with the principles of the Declaration of Helsinki and was approved by the Institutional Review Boards of participating institutions. The requirement for written informed consent was waived as it involved secondary analysis of de-identified data.

References

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    1. Hasle H, Clemmensen IH, Mikkelsen M. Risks of leukaemia and solid tumours in individuals with Down’s syndrome. Lancet Lond Engl. 2000;355:165–9. - DOI
    1. Lupo PJ, Schraw JM, Desrosiers TA, Nembhard WN, Langlois PH, Canfield MA, et al. Association between birth defects and cancer risk among children and adolescents in a population-based assessment of 10 million live births. JAMA Oncol. 2019;5:1150–8. - DOI - PubMed
    1. Buitenkamp TD, Izraeli S, Zimmermann M, Forestier E, Heerema NA, van den Heuvel-Eibrink MM, et al. Acute lymphoblastic leukemia in children with Down syndrome: a retrospective analysis from the Ponte di Legno study group. Blood. 2014;123:70–7. - DOI - PubMed - PMC
    1. Rabin KR, Devidas M, Chen Z, Ji L, Kairalla J, Hitzler JK, et al. Outcomes in children, adolescents, and young adults with down syndrome and ALL: A report from the Children’s Oncology Group. J Clin Oncol J Am Soc Clin Oncol. 2024;42:218–27. - DOI

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