doi: 10.1139/o77-010.
Action of inhibitors on monoamine and diamine metabolism in the rat
- PMID: 402175
- DOI: 10.1139/o77-010
Item in Clipboard
Action of inhibitors on monoamine and diamine metabolism in the rat
Can J Biochem.
1977 Jan.
Abstract
The effects of a series of inhibitors of monoamine oxidase (EC 1.4.3.4) and diamine oxidase (EC 1.4.3.6) and of two chelating agents were studied in rats, with respect to the catabolism of labeled pentylamine and putrescine to radioactive carbon dioxide. D-Tranylcypromine, clorgyline, and deprenyl inhibited oxidation of the monoamine, with essentially no effect on putrescine, under our test conditions. Aminoguanidine inhibited putrescine but not pentylamine oxidation. Iproniazid, isoniazid, and Lilly 51641 affected the catabolism of both amines. Pargyline inhibited putrescine oxidation, apparently in a reversible manner.
Similar articles
-
Putrescine metabolism and the study of diamine oxidase activity in vivo.Agents Actions. 1981 Apr;11(1-2):20-7. doi: 10.1007/BF01991449. Agents Actions. 1981. PMID: 6787849 Review.
-
The effects of chronic administration of inhibitors of flavin and quinone amine oxidases on imidazoline I(1) receptor density in rat whole brain.Ann N Y Acad Sci. 2003 Dec;1009:309-22. doi: 10.1196/annals.1304.040. Ann N Y Acad Sci. 2003. PMID: 15028605
-
Putrescine catabolism in rats given heparin or aminoguanidine.Eur J Pharmacol. 1980 Jun 27;64(4):307-11. doi: 10.1016/0014-2999(80)90238-1. Eur J Pharmacol. 1980. PMID: 6771147
-
Monoacylcadaverines as substrates for both monoamine oxidase and diamine oxidase; low rates of activity.Experientia. 1980 May 15;36(5):535-7. doi: 10.1007/BF01965783. Experientia. 1980. PMID: 6769699
-
The acetylenic monoamine oxidase inhibitors clorgyline, deprenyl, pargyline and J-508: their properties and applications.J Pharm Pharmacol. 1981 Jun;33(6):341-7. doi: 10.1111/j.2042-7158.1981.tb13800.x. J Pharm Pharmacol. 1981. PMID: 6115003 Review. No abstract available.
Cited by
-
Putrescine metabolism and the study of diamine oxidase activity in vivo.Agents Actions. 1981 Apr;11(1-2):20-7. doi: 10.1007/BF01991449. Agents Actions. 1981. PMID: 6787849 Review.
-
Inhibition of diamine oxidase by antimalarial drugs.Agents Actions. 1980 Nov;10(5):395-8. doi: 10.1007/BF01968035. Agents Actions. 1980. PMID: 6782842
MeSH terms
Substances
LinkOut - more resources
Full Text Sources