Lights and Shadows on Artificial Intelligence in Glaucoma: Transforming Screening, Monitoring, and Prognosis

Abstract

Background/Objectives: Artificial intelligence (AI) is increasingly being integrated into medicine, including ophthalmology, owing to its strong capabilities in image recognition. Methods: This review focuses on the most recent key applications of AI in the diagnosis and management of, as well as research on, glaucoma by performing a systematic review of the latest papers in the literature. Results: In glaucoma, AI can help analyze large amounts of data from diagnostic tools, such as fundus images, optical coherence tomography scans, and visual field tests. Conclusions: AI technologies can enhance the accuracy of glaucoma diagnoses and could provide significant economic benefits by automating routine tasks, improving diagnostic accuracy, and enhancing access to care, especially in underserved areas. However, despite these promising results, challenges persist, including limited dataset size and diversity, class imbalance, the need to optimize models for early detection, and the integration of multimodal data into clinical practice. Currently, ophthalmologists are expected to continue playing a leading role in managing glaucomatous eyes and overseeing the development and validation of AI tools.

Keywords: artificial intelligence; deep learning; fundus imaging; glaucoma; machine learning; optical coherence tomography; visual field test.

Figure 1

Machine learning branches.

Figure 2

Possible applications of AI in glaucoma.