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. 2025 Mar 23;14(7):2194.
doi: 10.3390/jcm14072194.

Comparison of Three Different Techniques for the Treatment of Cartilage Lesions-Matrix-Induced Autologous Chondrocyte Implantation (MACI) Versus Autologous Matrix-Induced Chondrogenesis (AMIC) and Arthroscopic Minced Cartilage-A 2-Year Follow-Up on Patient-Reported Pain and Functional Outcomes

Stefan Schneider  1 , Dagmar Linnhoff  1 , Ansgar Ilg  1 , Gian M Salzmann  2   3 , Robert Ossendorff  4 , Johannes Holz  1   5
Affiliations

Comparison of Three Different Techniques for the Treatment of Cartilage Lesions-Matrix-Induced Autologous Chondrocyte Implantation (MACI) Versus Autologous Matrix-Induced Chondrogenesis (AMIC) and Arthroscopic Minced Cartilage-A 2-Year Follow-Up on Patient-Reported Pain and Functional Outcomes

Stefan Schneider et al. J Clin Med. .

Abstract

Background/Objectives: The treatment of cartilage damage is an ongoing challenge. Several techniques have been developed to address this problem. Matrix-Induced Autologous Chondrocyte Implantation (MACI) is often referred to as the "gold standard" for cartilage treatment. Numerous long-term outcome studies also have reported favorable results with Autologous Matrix-Induced Chondrogenesis (AMIC). Minced Cartilage Implantation (MCI) is a recently developed arthroscopic method. This technique has demonstrated promising outcomes, with the prospect of longer-term results still under investigation. This study aims to directly compare the patient-reported outcomes of these three techniques over a 2-year follow-up period. Methods: A total of N = 48 patients were included in the retrospective matched pair analysis (n = 16 MACI, n = 16 AMIC, n = 16 MCI). VAS, KOOS-Pain, and KOOS-Symptoms scores served as primary outcomes; the KOOS-ADL and -QOL and the Tegner Activity Scale (TAS) served as secondary outcomes. Results: All three groups did not differ from each other in the primary or secondary outcomes. Pain and function significantly improved from pre-surgery to two years after (VAS: p < 0.000; ES: η2 = 0.27; KOOS-Pain: p < 0.000; ES: η2 = 0.30; KOOS-Symptoms: p = 0.000; ES: η2 = 0.26; KOOS-ADL: p > 0.000; ES: η2 = 0.20; KOOS-QOL: p > 0.000; ES: η2 = 0.30). There was no significant effect of time on the activity level. Conclusions: All three procedures show good patient-reported outcomes, low complication rates, and long graft longevity in the 2-year follow-up. Therefore, all three methods seem to be equally recommendable for the treatment of cartilage lesions.

Keywords: cartilage lesion; orthobiologics; regenerative therapy.

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Conflict of interest statement

The authors received financial support for the publication costs by Arthrex GmbH, Munich.

Figures

Figure 1
Figure 1
VAS scores for all three groups for all four time points. “+” indicates the mean, and outliers are indicated by triangles.
Figure 2
Figure 2
KOOS-Pain scores for all three groups for all four time points. “+” indicates the mean, and outliers are indicated by triangles.
Figure 3
Figure 3
KOOS-Symptoms scores for all three groups for all four time points. “+” indicates the mean, and outliers are indicated by triangles.
See this image and copyright information in PMC

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