The Association of Achromobacter xylosoxidans Airway Infection with Disease Severity in Cystic Fibrosis

Abstract

Background/Objectives: The prevalence of Achromobacter xylosoxidans is increasing in people with Cystic Fibrosis (pwCF), yet its clinical pathogenicity remains controversial. The objective of this study was to chart the longitudinal prevalence and examine clinical associations before and after infection. Methods: This observational, retrospective study was conducted at a single CF center over a 14-year period. Data were collated from patient charts and clinic databases. Patients with Achromobacter sputum cultures were compared to those without the bacterium and analyzed according to whether they had single, intermittent, or chronic infections. Results: During the study period, an annual average of 124 pwCF were followed up at our clinic, with a median age of 13.6 years (IQR = 7.6-27.7). The Achromobacter detection rate increased from 0 to 6.1%. Twenty-three percent (29/124) of patients had at least one positive culture. The median age at acquisition was 17 years (IQR = 14.5-33). At the time of acquisition, the median FEV₁ was 81% (IQR = 46-94), compared to 90% (IQR = 72-99) for patients without Achromobacter, p < 0.001. Patients with Achromobacter tended to demonstrate more chronic Pseudomonas (55% vs. 27%, p = 0.06) and pancreatic insufficiency (66% vs. 47%, p = 0.07). At two years post-acquisition, the median FEV₁ for patients with intermittent and chronically infected decreased by 11.5% (IQR = -3.75-7.5), compared to 1.5% (IQR = -2.5-12.5) for those with a single positive culture, p = 0.03. Similarly, pulmonary exacerbations per year became more frequent post-acquisition in intermittent and chronically infected patients: Median (range) 2.5 (0-8) pre-, versus 3.0 (0-9) post-acquisition, p = 0.036. Conclusions: Chronic and intermittent infection with Achromobacter were associated with accelerated lung function decline and increased exacerbation frequency. Larger prospective studies are needed to confirm these findings and examine the effect of eradication on the clinical course.

Keywords: Achromobacter xylosoxidans; Cystic Fibrosis; chronic infection; lung function.

Figure 1

Percent of patients with CF with any A. xylosoxidans-positive sputum culture (single, intermittent, and chronic) of total CF clinic population per year.

Figure 2

Median annual FEV₁ percent predicted (error bars showing IQR) of patients with intermittent and chronic A. xylosoxidans, compared to patients with a single culture, from acquisition until 2 years after.