Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2025 Apr 3;14(7):2447.
doi: 10.3390/jcm14072447.

The Association Between Periodontal Disease and Acute Coronary Syndrome-A Clinical Analysis

Marius Rus  1   2 , Bianca Maria Negruțiu  3 , Cristian Nicolae Sava  1 , Georgeta Pasca  4 , Felicia Liana Andronie-Cioara  4 , Simina Crisan  5 , Mircea-Ioachim Popescu  1   2 , Claudia Elena Staniș  6 , Claudia Judea Pusta  7
Affiliations

The Association Between Periodontal Disease and Acute Coronary Syndrome-A Clinical Analysis

Marius Rus et al. J Clin Med. .

Abstract

Background: This study investigated the association between periodontal disease and acute coronary syndrome (ACS), while examining periodontitis as an independent predictor of STEMI. Materials and Methods: This study included 166 patients with ACS, of whom 103 had a history of periodontal disease. Results: The results showed that patients with periodontal disease were more likely to have a history of tobacco use (78.6%), diabetes (53.1%), and poor oral hygiene (72.8%). This study also found a significant association between periodontal disease and the severity of ACS (STEMI-44.7%, three-vessel/LM disease-30.1%), with patients experiencing more frequent and severe cardiovascular complications (HF-51.6%, valvulopathy and mechanical complications-22.6%, arrhythmias-19.4%). The findings support previous studies suggesting a link between periodontal disease and cardiovascular risk. This study highlights the importance of considering periodontal disease as a potential risk factor for cardiovascular disease and the need for improved access to oral health care to reduce the burden of cardiovascular events. Conclusions: Periodontal disease was identified as an independent predictor of STEMI, highlighting the need for periodontal health assessments as part of routine management in cardiovascular risk stratification. The precise mechanisms continue to be an area of active investigation.

Keywords: acute coronary syndrome; cardiovascular risk; coronary artery disease; diabetes; periodontal disease; prevention; smoking.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Patient enrollment.
Figure 2
Figure 2
Distribution of patients according to age and the existence of periodontitis.
Figure 3
Figure 3
Distribution of patients according to gender and the existence of periodontitis.
Figure 4
Figure 4
Distribution of patients according to background and the existence of periodontitis.
Figure 5
Figure 5
Distribution of patients according to the type of ACS and the existence of periodontitis.
Figure 6
Figure 6
Distribution of patients according to smoking status and existence of periodontitis.
Figure 7
Figure 7
Distribution of the patients according to coronary artery disease and the existence of periodontitis.
Figure 8
Figure 8
Distribution of the patients according to the existence of high blood pressure, heart failure, and periodontitis.
Figure 9
Figure 9
Distribution of patients according to the appearance of cardiovascular complications and the existence of periodontitis.
Figure 10
Figure 10
Distribution of patients according to the type of cardiovascular complications and the existence of periodontitis.
Figure 11
Figure 11
Distribution of the patients according to the type of treatment and the existence of periodontitis.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Sanz M., del Castillo A.M., Jepsen S., Gonzalez-Juanatey J.R., D’Aiuto F., Bouchard P., Chapple I., Dietrich T., Gotsman I., Graziani F., et al. Periodontitis and cardiovascular diseases: Consensus report. J. Clin. Periodontol. 2020;47:268–288. doi: 10.1111/jcpe.13189. - DOI - PMC - PubMed
    1. Liccardo D., Cannavo A., Spagnuolo G., Ferrara N., Cittadini A., Rengo C., Rengo G. Periodontal Disease: A Risk Factor for Diabetes and Cardiovascular Disease. Int. J. Mol. Sci. 2019;20:1414. doi: 10.3390/ijms20061414. - DOI - PMC - PubMed
    1. Kilgare C. Periodontitis an Independent Risk Factor for CHD-coro-nary heart disease. Family Practice News, 1 August 2000. [(accessed on 31 March 2025)]. Available online: https://www.thefreelibrary.com/Periodontitis+an+Independent+Risk+Factor+....
    1. Beck J.D., Offenbacher S. Systemic Effects of Periodontitis: Epidemiology of Periodontal Disease and Cardiovascular Disease. J. Periodontol. 2005;76:2089–2100. doi: 10.1902/jop.2005.76.11-S.2089. - DOI - PubMed
    1. Hobbs F., Piepoli M., Hoes A., Agewall S., Albus C., Brotons C., Catapano A., Cooney M., Corra U., Cosyns B., et al. 2016 European Guidelines on Cardiovascular Disease Prevention in Clinical Practice. Eur. Heart J. 2016;37:2315–2381. doi: 10.1093/eurheartj/ehw106. - DOI - PMC - PubMed

LinkOut - more resources