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Review
. 2025 Apr 7;14(7):2505.
doi: 10.3390/jcm14072505.

Hepatitis B-Induced Hepatocellular Carcinoma: Understanding Viral Carcinogenesis and Disease Management

Yasamin Farbod  1 , Husain Kankouni  2 , Maryam Moini  3 , Scott Fung  4
Affiliations
Review

Hepatitis B-Induced Hepatocellular Carcinoma: Understanding Viral Carcinogenesis and Disease Management

Yasamin Farbod et al. J Clin Med. .

Abstract

Hepatitis B virus (HBV) infection is a leading cause of chronic liver disease and liver cancer worldwide. Hepatocellular carcinoma (HCC) remains one of the major causes of cancer-related mortality globally. Effective prevention and management strategies for HBV infection are crucial in reducing liver-related complications, including HCC. HBV plays a distinct role in liver carcinogenesis, and there is growing knowledge about the factors contributing to its oncogenic potential. With advancements in HCC management, special attention must be given to the treatment of HBV infection in patients with HBV-induced HCC. In this review, we summarize current insights into the carcinogenic mechanisms of HBV and discuss the latest approaches to managing HBV-induced HCC.

Keywords: antiviral therapy; hepatitis B virus (HBV); hepatocellular carcinoma (HCC).

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Conflict of interest statement

The authors declare no conflict of interest related to this paper.

Figures

Figure 1
Figure 1
Global prevalence of hepatitis B infection.
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