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Review
. 2025 Mar 25;13(7):726.
doi: 10.3390/healthcare13070726.

Sarcopenia as a Prognostic Factor for the Outcomes of Surgical Treatment of Colorectal Carcinoma

Šimon Leščák  1 , Martina Košíková  2 , Sylvia Jenčová  2
Affiliations
Review

Sarcopenia as a Prognostic Factor for the Outcomes of Surgical Treatment of Colorectal Carcinoma

Šimon Leščák et al. Healthcare (Basel). .

Abstract

Background/Objectives: Sarcopenia, defined as the progressive loss of muscle mass and function, is increasingly associated with worse outcomes in the surgical treatment of colorectal cancer (CRC). This paper focuses on analyzing the impact of sarcopenia as a prognostic factor on postoperative outcomes in CRC patients. The aim of the study is to identify the main factors influencing postoperative results. This will be accomplished via bibliometric analysis and highlighting the significance of muscle condition in the preoperative assessment of patients. Methods: The methodological approach involves analyzing bibliographic data from relevant scientific databases focused on sarcopenia and oncological surgery. The study employs a quantitative analysis of citations and collaborations among authors and institutions. The focus will be on research publications from 2013, when we first identified references to sarcopenia in the examined context. Results: The results show that sarcopenia significantly increases the risk of postoperative morbidity and mortality in CRC patients. Network analysis and keyword mapping reveal dominant research topics such as muscle condition, mortality, and postoperative complications. Meanwhile, we identify the need for standardized diagnostic methods for sarcopenia and their integration into clinical practice to improve predictive models and clinical approaches. Conclusions: These findings underscore the importance of interdisciplinary collaboration, preoperative assessment of muscle condition, and the implementation of standardized approaches to improve clinical outcomes for patients.

Keywords: bibliometric analysis; colorectal carcinoma; prognostic factor; sarcopenia; surgical treatment.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Trend of scientific publications examining sarcopenia as a prognostic factor for surgical treatment outcomes of colorectal cancer.
Figure 2
Figure 2
Trend of scientific publications on prognostic factors for outcomes of surgical treatment of colorectal cancer.
Figure 3
Figure 3
Web of Science research areas encompassing the identified scientific publications examining sarcopenia as a prognostic factor for surgical treatment outcomes of colorectal cancer.
Figure 4
Figure 4
Number of publications on sarcopenia as a prognostic factor for surgical treatment outcomes of colorectal cancer by country.
Figure 5
Figure 5
Number of publications on prognostic factors for outcomes of surgical treatment of colorectal cancer by country.
Figure 6
Figure 6
Bibliometric co-authorship map by country.
Figure 7
Figure 7
Bibliometric co-authorship map by author.
Figure 8
Figure 8
Bibliometric map of keyword occurrences.
Figure 9
Figure 9
Keyword cloud in the research on sarcopenia as a prognostic factor for surgical treatment outcomes of colorectal cancer in the publication by [14].
Figure 10
Figure 10
Keyword cloud for research on sarcopenia as a prognostic factor in surgical treatment outcomes of colorectal cancer in the publication by [16].
Figure 11
Figure 11
Keyword cloud for research on sarcopenia as a prognostic factor in surgical treatment outcomes of colorectal cancer from the publication by [13].
Figure 12
Figure 12
Keyword cloud for research on sarcopenia as a prognostic factor in surgical treatment outcomes of colorectal cancer from the publication by [132].
See this image and copyright information in PMC

References

    1. Morgan E., Arnold M., Gini A., Lorenzoni V., Cabasag C.J., Laversanne M., Vignat J., Ferlay J., Murphy N., Bray F. Global burden of colorectal cancer in 2020 and 2040: Incidence and mortality estimates from Globocan. Gut. 2022;72:338–344. doi: 10.1136/gutjnl-2022-327736. - DOI - PubMed
    1. Dekker E., Tanis P.J., Vleugels J.L., Kasi P.M., Wallace M.B. Colorectal cancer. Lancet. 2019;394:1467–1480. doi: 10.1016/s0140-6736(19)32319-0. - DOI - PubMed
    1. Cruz-Jentoft A.J., Bahat G., Bauer J., Boirie Y., Bruyère O., Cederholm T., Cooper C., Landi F., Rolland Y., Sayer A.A., et al. Sarcopenia: Revised European consensus on definition and diagnosis. Age Ageing. 2019;48:601. doi: 10.1093/ageing/afz046. - DOI - PMC - PubMed
    1. Joglekar S., Nau P.N., Mezhir J.J. The impact of sarcopenia on survival and complications in Surgical Oncology: A review of the current literature. J. Surg. Oncol. 2015;112:503–509. doi: 10.1002/jso.24025. - DOI - PMC - PubMed
    1. Park S.S., Kwon E.-S., Kwon K.-S. Molecular mechanisms and therapeutic interventions in Sarcopenia. Osteoporos. Sarcopenia. 2017;3:117–122. doi: 10.1016/j.afos.2017.08.098. - DOI - PMC - PubMed

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