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Review
. 2025 Apr 12;24(2):37.
doi: 10.1007/s10689-025-00463-x.

One hundred years of the St Mark's hospital polyposis registry

Vicky Cuthill  1 , Andy Latchford  1   2 , Sue Clark  3   4
Affiliations
Review

One hundred years of the St Mark's hospital polyposis registry

Vicky Cuthill et al. Fam Cancer. .

Abstract

The St Mark's Hospital Polyposis Registry was founded in 1924, the first such unit in the world. This paper documents the development of the unit over the subsequent 100 years, which was inextricably linked to scientific and clinical advance in the field of polyposis syndromes.

Keywords: Data collection; Familial adenomatous polyposis; Juvenile polyposis syndrome; Peutz-Jeghers syndrome; Registries.

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Conflict of interest statement

Declarations. Competing interests: All three authors work at the St Mark’s Hospital Polyposis Registry, the subject of this article. Andy Latchford is current Director of the unit, and Sue Clark held that post previously.

Figures

Fig. 1
Fig. 1
Cuthbert Dukes (left) and Percy Lockhart-Mummery (right)
Fig. 2
Fig. 2
Dick Bussey in the pathology laboratory at St Mark’s c1924 and still at work cutting up polyposis specimens c1990
Fig. 3
Fig. 3
An original pedigree and longitudinal record of polyp progression
Fig. 4
Fig. 4
Directors of the St Mark’s Hospital Polyposis Registry at the Centenary dinner March 2024. Left to right: Sue Clark (2013-22), James Thomson (1985-92), Robin Phillips (1993–2012), Andy Latchford (2023-)
Fig. 5
Fig. 5
Kay Neale (left) and Vicky Cuthill (right) at the Centenary dinner
Fig. 6
Fig. 6
Timeline of the St Mark’s Hospital Polyposis Registry
See this image and copyright information in PMC

References

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    1. Cripps WH Two cases of disseminated polypus of the rectum. Trans Pathol Soc Lond 1882; 33:165–168
    1. Lockhart-Mummery (1936) JP. After Us. Stanley Paul, London
    1. Lockhart-Mummery JP (1925) Cancer Heredity Lancet 1:427–429
    1. Dukes CE (1930) The hereditary factor in polyposis intestine, or multiple adenomata. Cancer Rev 5:241–256

MeSH terms