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. 2025 Oct;57(10):3327-3339.
doi: 10.1007/s11255-025-04511-4. Epub 2025 Apr 12.

Identification of risk factors for renal progression in adults with IgAV: a retrospective cohort study of a single center in northwest China

Yingying Wang #  1   2   3   4 , Xiaochun Zhou #  1   2   3   4 , Gang Cheng  1   3   4 , Rongrong Zhu  1   3   4 , Zizhao Qi  1   3   4 , Wenjun Zhang  1   2   3   4 , Hong Shu  1   2   3   4 , Wei Liu  1   2   3   4 , Gouqin Wang  1   2   3   4 , Qian Pu  1   2   3   4 , Yuke Kong  1   2   3   4 , Jianqin Wang  5   6   7   8
Affiliations

Identification of risk factors for renal progression in adults with IgAV: a retrospective cohort study of a single center in northwest China

Yingying Wang et al. Int Urol Nephrol. 2025 Oct.

Abstract

Objectives: This investigation sought to examine the clinical and pathological characteristics, outcomes, and risk factors linked to the progression of renal function in adult-onset immunoglobulin A (IgA) vasculitis within a single center in northwest China.

Methods: Data were retrospectively gathered from cases of adult-onset IgA vasculitis recorded at a tertiary hospital in northwest China, covering the period from January 2013 to August 2024. During the follow-up, clinical information was compared between patients who advanced to chronic kidney disease (CKD) stage 3 and those who did not.

Results: A sum of 1082 adult-onset IgA vasculitis patients (632 men; median age of 37 years) were included. Among patients with baseline proteinuria >0.5 g/24h (43.9%), 40.7% progressed to chronic kidney disease (CKD) stage 3, while 5.1% developed end-stage renal disease (ESRD). COX regression analysis indicated that older age, renal pathological grade IV, hypertension (HTN), diabetes, hyperlipidemia, and hyperuricemia were independent risk factors for CKD stage 3 progression in individuals with adult-onset IgA vasculitis.

Conclusions: Older age and comorbidities such as hypertension and diabetes significantly increase the risk of renal progression in adult-onset IgAV. Early management of these comorbidities may mitigate the risk of CKD progression.

Keywords: Adult onset IgA vasculitis; Chronic kidney disease; Henoch schönlein purpura; Risk factor.

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Conflict of interest statement

Declarations. Competing interest: The authors declare no competing interests.

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