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Case Reports
. 2025 Oct;54(10):2193-2198.
doi: 10.1007/s00256-025-04929-y. Epub 2025 Apr 13.

A rare case of atypical ossifying fibromyxoid tumor: multiple recurrences and metastasis

Zichun Huang  1 , Guohong Liu  2
Affiliations
Case Reports

A rare case of atypical ossifying fibromyxoid tumor: multiple recurrences and metastasis

Zichun Huang et al. Skeletal Radiol. 2025 Oct.

Abstract

Ossifying fibromyxoid tumor is a rare soft tissue mesenchymal neoplasm of unclear lineage and intermediate malignant potential, primarily arising in subcutaneous tissues of the limbs, head and neck, or trunk. Ossifying fibromyxoid tumors can be classified as typical, atypical, or malignant. While, most ossifying fibromyxoid tumors exhibit benign behavior, a subset demonstrates malignant tendencies, with a potential for local recurrence and distant metastasis. We report a case of an atypical ossifying fibromyxoid tumor in the soft tissue of the right elbow, characterized by multiple local recurrences and pulmonary metastases. This report details the clinical presentation, radiological findings, histopathological features, and therapeutic interventions, highlighting the challenges in managing this aggressive variant.

Keywords: Metastases; Ossifying fibromyxoid tumor; Radiological feature; Recurrence.

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Conflict of interest statement

Declarations. Ethics approval: All procedures performed in studies involving human participants were conducted in accordance with the ethical standards of the institutional and/or national research committee and in accordance with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Informed consent: Informed consent was obtained from the subject described in this report. Competing interests: The authors declare no competing interest.

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References

    1. Enzinger FM, Weiss SW, Liang CY. Ossifying fibromyxoid tumor of soft parts. A clinicopathological analysis of 59 cases. Am J Surg Pathol. 1989;13(10):817–27. - PubMed
    1. Argani P, Dickson BC, Gross JM, Matoso A, Baraban E, Antonescu CR. Ossifying fibromyxoid tumor of the genitourinary tract: report of 4 molecularly confirmed cases of a diagnostic pitfall. Am J Surg Pathol. 2023;47(6):709–16. - PubMed - PMC
    1. Folpe AL, Weiss SW. Ossifying fibromyxoid tumor of soft parts: a clinicopathologic study of 70 cases with emphasis on atypical and malignant variants. Am J Surg Pathol. 2003;27(4):421–31. - PubMed
    1. Endo M, Mertens F, Miettinen M. WHO classifcation of tumors of soft tissue and bone tumors, 5th Edition, Volume 3. Lyon: IARC. 2020;274–276.
    1. Carter CS, Patel RM. Ossifying fibromyxoid tumor: a review with emphasis on recent molecular advances and differential diagnosis. Arch Pathol Lab Med. 2019;143(12):1504–12. - PubMed

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